2010 Fiscal Year Final Research Report
VLDLR overexpression rat : evaluation as an animal model of autism
| Project/Area Number |
21791126
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
IWATA Keiko Hamamatsu University School of Medicine, 子どものこころの発達研究センター, 助教 (30415088)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 児童 / 思春期精神医学 |
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| Research Abstract |
It has been reported that level of VLDLR mRNA was increased in post mortem studies of autistic brain. In this study, we generated transgenic (Tg) rats overexpressing VLDLR and examined its histological and behavioral features. Results indicated that the spontaneous locomotor activity in Tg rats was significantly increased without detectable changes in histology. Additionally, Tg rats tended to show performance deficits in radial maze, suggesting that spatial working memory was slightly impaired. These results suggest that VLDLR level might be involved in locomotor activity and memory function. Patients with neurodevelopmental or psychiatric disorders do not show striking neuroanatomical aberration. Therefore, it is significant for the clinical aspect that these behavioral phenotypes were detected without neuroanatomical abnormality in VLDLR Tg rats.
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Research Products
(10 results)
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[Journal Article] Reduced expression of apolipoprotein E receptor type 2 in peripheral blood lymphocytes from patients with major depressive disorder.2010
Author(s)
Suzuki K, Iwata Y, Matsuzaki H, Anitha A, Suda S, Iwata K, Shinmura C, Kameno Y, Tsuchiya KJ, Nakamura K, Takei N, Mori N.
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Journal Title
Prog Neuropsychopharmacol Biol Psychiatry. 34
Pages: 1007-1010
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[Journal Article] Failure to confirm genetic association of the FXYD6 gene with schizophrenia : the Japanese population and meta-analysis.2010
Author(s)
Iwata Y, Yamada K, Iwayama Y, Anitha A, Thanseem I, Toyota T, Hattori E, Ohnishi T, Maekawa M, Nakamura K, Suzuki K, Matsuzaki H, Tsuchiya KJ, Suda S, Sugihara G, Takebayashi K, Yamamoto S, Iwata K, Mori N, Yoshikawa T.
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Journal Title
Am J Med Genet B Neuropsychiatr Genet. B 153
Pages: 1221-1227
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[Journal Article] Destruction of dopaminergic neurons in the midbrain by 6-hydroxydopamine decreases hippocampal cell proliferation in rats : reversal by fluoxetine.2010
Author(s)
Suzuki K, Okada K, Wakuda T, Shinmura C, Kameno Y, Iwata K, Takahashi T, Suda S, Matsuzaki H, Iwata Y, Hashimoto K, Mori N.
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Journal Title
PLoS One 17;5(2)
Pages: e9260
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[Journal Article] Decreased serum levels of adiponectin in subjects with autism.2010
Author(s)
Fujita-Shimizu A, Suzuki K, Nakamura K, Miyachi T, Matsuzaki H, Kajizuka M, Shinmura C, Iwata Y, Suda S, Tsuchiya KJ, Matsumoto K, Sugihara G, Iwata K, Yamamoto S, Tsujii M, Sugiyama T, Takei N, Mori N.
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Journal Title
Prog Neuropsychopharmacol Biol Psychiatry. 34
Pages: 455-458
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[Journal Article] Serum levels of platelet-derived growth factor BB homodimers are increased in male children with autism.2010
Author(s)
Kajizuka M, Miyachi T, Matsuzaki H, Iwata K, Shinmura C, Suzuki K, Suda S, Tsuchiya KJ, Matsumoto K, Iwata Y, Nakamura K, Tsujii M, Sugiyama T, Takei N, Mori N.
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Journal Title
Prog Neuropsychopharmacol Biol Psychiatry 34
Pages: 154-158
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[Presentation] VLDLR overexpression rat : evaluation as an animal model of autism.2010
Author(s)
Iwata, K., Matsuzaki, H., Izumo, N., Ichitani, Y., Mori, N.
Organizer
Society for neuroscience 2010
Place of Presentation
San Diego, California
Year and Date
20101113-20101116
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[Remarks] ホームページ等
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