2011 Fiscal Year Final Research Report
Establishment of objective evaluation of medication effect for Attention-deficit/hyperactivity disorder with near-infrared spectroscopy.
| Project/Area Number |
21791129
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Nagoya University |
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Principal Investigator |
YOSHIKAWA Toru 名古屋大学, 医学部附属病院, 助教 (70456680)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 注意欠陥多動性障害 / 近赤外線分光法(NIRS) / 薬物療法 / 前頭葉機能 |
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| Research Abstract |
The number of children given a diagnosis of attention-deficit/hyperactivity disorder(ADHD) increases year by year in Japan. And methylphenidate(MPH) is often prescribed to treat individuals diagnosed with ADHD. The development of a simple and convenient effect measurement method of MPH is demanded. Ten children with ADHD under MPH medication participated in the present study. The relative concentrations of oxyhemoglobin(oxy-Hb) and deoxyhemoglobin(deoxy-Hb) were measured with frontal probes during the continuous performance test(CPT), using a NIRS machine. Compared with the off-MPH condition, mean reaction time is shorter and the number of omission error is smaller in the on-MPH condition. During the CPT, the oxy-Hb were significantly larger and deoxy-Hb were slightly larger than baseline in the bilateral frontal probes. But there is no statistically significant difference between on-and off-MPH conditions. The large individual differences of NIRS signal and small number of cases are the limitations. It will be necessary to increase number of cases in future study.
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Research Products
(15 results)
