2010 Fiscal Year Final Research Report
PET study of dopamine receptor and psychiatric symptoms in patients with temporal epilepsy
| Project/Area Number |
21791150
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Nippon Medical School |
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Principal Investigator |
ICHIMIYA Tetsuya Nippon Medical School, 医学部, 講師 (50398864)
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| Project Period (FY) |
2009 – 2010
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| Keywords | PET / ドパミンD2 / 側頭葉てんかん |
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| Research Abstract |
Nine patients with left temporal lobe epilepsy and age-matched 14 healthy control subjects participated in this study. Binding potential of dopamine D2 receptors were examined using positron emission tomography. Parametric images of binding potentials were created and compared between groups. Binding potentials in the left temporal lobe, left inferior temporal lobe, left fusiform gyrus were decreased in patients compared to control subject. This could indicate decreased dopamine D2 neurotransmission in the ipsilateral temporal lobe.
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