2011 Fiscal Year Final Research Report
Detection of mitochondrial DNA defects in GABAergic neurons of model mice for bipolar disorder
| Project/Area Number |
21791157
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Psychiatric science
|
|---|
| Research Institution | The Institute of Physical and Chemical Research |
|---|
Principal Investigator |
KUBOTA Mie (坂下 美恵) 独立行政法人理化学研究所, 精神疾患動態研究チーム, 専門職研究員 (90344035)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | Mitochondria / polymerase gamma / mitochondrial DNA / bipolar disorder / GFP |
|---|
| Research Abstract |
We detected the distribution of mtDNA deficient neurons with loss of mitochondrial proteins in transgenic mice expressing neuron-specific mutant mitochondria DNA polymerase by immunohistochemistry with antibodies against mtDNA-encoded or nuclear-encoded mitochondrial proteins.
|
