2010 Fiscal Year Final Research Report
Development of a VEGFR3 imaging agent by PET for predictive diagnosis of lymph node metastasis.
| Project/Area Number |
21791168
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Tohoku University |
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Principal Investigator |
FURUMOTO Shozo Tohoku University, 大学院・医学系研究科, 准教授 (00375198)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 放射性医薬品 / 造影剤 |
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| Research Abstract |
The purpose of this study was to develop a new radiolabeled imaging probe to visualize a VEGFR3 receptor, which is a key molecule in the early process of lymph node metastasis. Thus, imaging of VEGFR3 would be applicable to early diagnosis of lymph node metastasis. In this study, 11C-labeled VEGFR3 and its precursor for radiolabeling by methylation was successfully synthesized. Small animal PET imaging with the tracer showed a radioactivity uptake in tumor tissue in an AH109A tumor bearing rat.
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