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2010 Fiscal Year Final Research Report

Clinical trial of proton beam therapy for the patients with hepatocellular carcinoma

Research Project

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Project/Area Number 21791170
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionUniversity of Tsukuba

Principal Investigator

MASASHI Mizumoto  University of Tsukuba, 大学院・人間総合科学研究科, 講師 (20512388)

Project Period (FY) 2009 – 2010
Keywords粒子線治療
Research Abstract

The first year, we analyzed Dose Volume Histgram (DVH) of the patients with hepatocellular carcinoma (HCC) treated by proton beam therapy at University of Tsukuba. Along with this analysis, we reviewed late toxicity such as digestive tract ulcer, rib fracture and loss of liver function.
In the second year, we analyzed effectiveness and adverse event of proton beam therapy. In the result, we concluded that select optimal treatment schedule according to tumor location is useful to perform proton beam therapy safety. Especially the patients having HCC near the digestive tract need careful treatment to avoid digestive tract ulcer and bleeding.
And in this analysis, refractory HCC (such as large HCC, portal vein tumor thrombus and inferior vena tumor thrombus) could be well controlled by proton beam therapy without sever toxicity.
We also analyze the change of liver function after proton beam therapy. From this analysis, minimize the irradiated area of normal liver is important factor to keep good liver function after proton beam therapy.

  • Research Products

    (19 results)

All 2011 2010 2009

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (6 results)

  • [Journal Article] Proton Beam Therapy for Hepatocellular Carcinoma : A Comparison of Three Treatment Protocols.2011

    • Author(s)
      Mizumoto M, Okumura T, Hashimoto T, Fukuda K, Oshiro Y, Fukumitsu N, Abei M, Kawaguchi A, Hayashi Y, Ookawa A, Hashii H, Kanemoto A, Moritake T, Tohno E, Tsuboi K, Sakae T, Sakurai H
    • Journal Title

      International journal of radiation oncology biology physics Epub ahead of print

    • Peer Reviewed
  • [Journal Article] Investigation of the Geometric Accuracy of Proton Beam Irradiation in the Liver.2011

    • Author(s)
      Fukumitsu N, Hashimoto T, Okumura T, Mizumoto M, Tohno E, Fukuda K, Abei M, Sakae T, Sakurai H
    • Journal Title

      International journal of radiation oncology biology physics Epub ahead of print

    • Peer Reviewed
  • [Journal Article] Pediatric nasopharyngeal carcinoma treated with proton beam therapy.2011

    • Author(s)
      Oshiro Y, Sugahara S, Fukushima T, Okumura T, Nakao T, Mizumoto M, Hashimoto T, Tsuboi K, Kaneko M, Sakurai H
    • Journal Title

      Two case reports.Acta Oncol Epub ahead of print

    • Peer Reviewed
  • [Journal Article] Radiotherapy for patients with metastases to the spinal column : a review of 603 patients at Shizuoka Cancer Center Hospital.2011

    • Author(s)
      Mizumoto M, Harada H, Asakura H, Hashimoto T, Furutani K, Hashii H, Murata H, Takagi T, Katagiri H, Takahashi M, Nishimura T
    • Journal Title

      International journal of radiation oncology biology physics Vol.79

      Pages: 208-213

    • Peer Reviewed
  • [Journal Article] Proton beam therapy for large hepatocellular carcinoma.2010

    • Author(s)
      Sugahara S, Oshiro Y, Nakayama H, Fukuda K, Mizumoto M, Abei M, Shoda J, Matsuzaki Y, Thono E, Tokita M, Tsuboi K, Tokuuye K
    • Journal Title

      International journal of radiation oncology biology physics Vol.76

      Pages: 460-466

    • Peer Reviewed
  • [Journal Article] Analysis of dose-volume histogram parameters for radiation pneumonitis after definitive concurrent chemoradiotherapy for esophageal cancer.2010

    • Author(s)
      Asakura H, Hashimoto T, Zenda S, Harada H, Hirakawa K, Mizumoto M, Furutani K, Hironaka S, Fuji H, Murayama S, Boku N, Nishimura T
    • Journal Title

      Radiother Oncol Vol.95

      Pages: 240-244

    • Peer Reviewed
  • [Journal Article] Palliative radiotherapy for bleeding from advanced gastric cancer : is a schedule of 30 Gy in 10 fractions adequate?.2010

    • Author(s)
      Asakura H, Hashimoto T, Harada H, Mizumoto M, Furutani K, Hasuike N, Matsuoka M, Ono H, Boku N, Nishimura T
    • Journal Title

      J Cancer Res Clin Oncol Vol.137

      Pages: 125-130

    • Peer Reviewed
  • [Journal Article] Clinical results of proton-beam therapy for locoregionally advanced esophageal cancer.2010

    • Author(s)
      Mizumoto M, Sugahara S, Nakayama H, Hashii H, Nakahara A, Terashima H, Okumura T, Tsuboi K, Tokuuye K, Sakurai H
    • Journal Title

      Strahlenther Onkol Vol.186

      Pages: 482-488

    • Peer Reviewed
  • [Journal Article] Phase I/II trial of hyperfractionated concomitant boost proton radiotherapy for supratentorial glioblastoma multiforme.2009

    • Author(s)
      Mizumoto M, Tsuboi K, Igaki H, Yamamoto T, Takano S, Oshiro Y, Hayashi Y, Hashii H, Kanemoto A, Nakayama H, Sugahara S, Sakurai H, Matsumura A, Tokuuye K
    • Journal Title

      International journal of radiation oncology biology physics Vol.77

      Pages: 98-105

    • Peer Reviewed
  • [Journal Article] Proton beam therapy for hepatocellular carcinoma : the University of Tsukuba experience.2009

    • Author(s)
      Nakayama H, Sugahara S, Tokita M, Fukuda K, Mizumoto M, Abei M, Shoda J, Sakurai H, Tsuboi K, Tokuuye K
    • Journal Title

      Cancer Vol.115

      Pages: 5499-5506

    • Peer Reviewed
  • [Journal Article] A prospective study of hypofractionated proton beam therapy for patients with hepatocellular carcinoma.2009

    • Author(s)
      Fukumitsu N, Sugahara S, Nakayama H, Fukuda K, Mizumoto M, Abei M, Shoda J, Thono E, Tsuboi K, Tokuuye K
    • Journal Title

      International journal of radiation oncology biology physics Vol.74

      Pages: 831-836

    • Peer Reviewed
  • [Journal Article] Technical considerations for noncoplanar proton-beam therapy of patients with tumors proximal to the optic nerve.2009

    • Author(s)
      Mizumoto M, Nakayama H, Tokita M, Sugahara S, Hashii H, Sakae T, Tsuboi K, Sakurai H, Tokuuye K
    • Journal Title

      Strahlenther Onkol Vol.186

      Pages: 36-39

    • Peer Reviewed
  • [Journal Article] Proton-beam therapy for hepatocellular carcinoma associated with portal vein tumor thrombosis.2009

    • Author(s)
      Sugahara S, Nakayama H, Fukuda K, Mizumoto M, Tokita M, Abei M, Shoda J, Matsuzaki Y, Thono E, Tsuboi K, Tokuuye K
    • Journal Title

      Strahlenther Onkol Vol.185

      Pages: 782-788

    • Peer Reviewed
  • [Presentation] 登院における頭蓋内腫瘍に対する陽子線治療の検討2010

    • Author(s)
      水本斉志, 他
    • Organizer
      日本放射線外科学会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-27
  • [Presentation] 筑波大学における肝細胞癌に対する陽子線治療2010

    • Author(s)
      水本斉志, 他
    • Organizer
      日本癌治療学会
    • Place of Presentation
      京都
    • Year and Date
      2010-10-29
  • [Presentation] Proton beam therapy for hepatocellular carcinoma : a comparison of three treatment protocols.2010

    • Author(s)
      水本斉志, 他
    • Organizer
      欧州放射線腫瘍学会
    • Place of Presentation
      バルセロナ,スペイン
    • Year and Date
      2010-09-13
  • [Presentation] A phase I/II clinical trial of hyperfractionated concomitant boost proton radiotherapy for supratentorial glioblastoma multiforme.2009

    • Author(s)
      坪井康次, 水本斉志, 他
    • Organizer
      米国放射線腫瘍学会
    • Place of Presentation
      シカゴ,米国
    • Year and Date
      2009-11-03
  • [Presentation] Hyperfractionated concomitant boost proton radiotherapy for supratentorial glioblastoma multiforme.2009

    • Author(s)
      坪井康次, 水本斉志, 他
    • Organizer
      国際陽子線治療学会
    • Place of Presentation
      ハイデルベルグ,ドイツ
    • Year and Date
      2009-09-29
  • [Presentation] 頭蓋底脊索腫/軟骨肉腫に対する陽子線治療の治療成績2009

    • Author(s)
      水本斉志, 他
    • Organizer
      日本放射線腫瘍学会
    • Place of Presentation
      京都
    • Year and Date
      2009-09-18

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Published: 2012-02-13   Modified: 2016-04-21  

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