2010 Fiscal Year Final Research Report
Research of aiming at the establishment of comprehensive diagnosis and therapy of metastatic bone cancer using novel radiopharmaceuticals
| Project/Area Number |
21791174
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Kanazawa University |
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Principal Investigator |
OGAWA Kazuma Kanazawa University, 薬学系, 准教授 (30347471)
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| Project Period (FY) |
2009 – 2010
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| Keywords | イメージング / PET / 転移性骨腫瘍 |
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| Research Abstract |
DOTA-conjugated bisphosphonate was synthesized using bisphosphonate as a carrier to bone. ^<67>Ga-DOTA-conjugated bisphosphonate was prepared with a radiochemical purity of over 95% without purification. In biodistribution experiments, ^<67>Ga-DOTA-conjugated bisphosphonate accumulated in bone rapidly but were hardly observed in tissues other than bone. These results indicate that ^<67>Ga-DOTA-conjugated bisphosphonate has ideal biodistribution characteristics as bone-imaging agents.
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