2010 Fiscal Year Final Research Report
Study on internal-radiotherapy with ^<64>Cu-ATSM targeting cancer stem cell-rich regions in tumors.
| Project/Area Number |
21791176
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | University of Fukui |
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Principal Investigator |
YOSHII Yukie University of Fukui, 高エネルギー医学研究センター, 特命助教 (10397242)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 画像診断学(含放射線診断学、核医学) / 内用放射線治療 / Positron Emission / Tomography / 腫瘍内低酸素 / がん幹細胞 / ^<64>Cu-ATSM |
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| Research Abstract |
^<64>Cu-ATSM therapy resulted in inhibition of tumor growth, reduction of cancer stem cells, decrease of metastatic potential of tumors, suggesting the possibility of new internal-radiotherapy.
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[Journal Article] Copper-64-diacetyl-bis (N4-methylthiosemicarbazone) accumulates in rich regions of CD133+ highly tumorigenic cells in mouse colon carcinoma.2010
Author(s)
Yukie Yoshii, Takako Furukawa, Yasushi Kiyono, Ryo Watanabe, Atsuo Waki, Tetsuya Mori, Hiroshi Yoshii, Myungmi Oh, Tatsuya Asai, Hidehiko Okazawa, Michael J.Welch, Yasuhisa Fujibayashi.
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Journal Title
Nuclear Medicine and Biology. 37
Pages: 395-404
Peer Reviewed
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[Journal Article] Development of positron emission tomography imaging by 64Cu-labeled Fab for detecting ERC/mesothelin in a mesothelioma mouse model.2010
Author(s)
Chisato Yoshida, Chizuru Sogawa, Atsushi Tsuji, Hitomi Sudo, Aya Sugyo, Tomoya Uehara, Okio Hino, Yukie Yoshii, Yasuhisa Fujibayashi, Toshimitsu Fukumura, Mitsuru Koizumi, Yasushi Arano, Tsuneo Saga.
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Journal Title
Nuclear Medicine Communications. 31
Pages: 380-388
Peer Reviewed
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[Presentation] 64Cu-ATSM イメージング:低酸素・栄養飢餓とがん幹細胞との関係に関する検討2009
Author(s)
吉井幸恵, 鈴木佑哉, 清野泰, 脇厚生, 渡辺亮, 森哲也, 吉井裕, 古川高子, 浅井竜哉, Michael J.Welch, 藤林靖久
Organizer
第49回日本核医学会
Place of Presentation
旭川
Year and Date
20091001-20091003
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[Presentation] 64Cu-ATSM imaging for cancer stem cell-rich regions : in vivo and in vitro characterization.2009
Author(s)
Yukie Yoshii, Yasushi Kiyono, Atsuo Waki, Ryo Watanabe, Yuya Suzuki, Tetsuya Mori, Hiroshi Yoshii, Takako Furukawa, Tatsuya Asai, Takashi Kudo, Hidehiko Okazawa, Michael J.Welch, Yasuhisa Fujibayashi.
Organizer
2009 World Molecular Imaging Congress
Place of Presentation
Montreal, Canada
Year and Date
20090923-20090926
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[Presentation] Hypoxia imaging agent 64Cu-ATSM visualizes cancer stem cell-rich regions within tumors.2009
Author(s)
Yukie Yoshii, Yasushi Kiyono, Ryo Watanabe, Atsuo Waki, Tetsuya Mori, Hiroshi Yoshii, Takako Furukawa, Myungmi Oh, Masato Kobayashi, Michael J.Welch, Yasuhisa Fujibayashi.
Organizer
The Society of Nuclear Medicine (SNM) annual meeting 2009
Place of Presentation
Toronto, Canada
Year and Date
20090613-20090617
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[Presentation] 64Cu-ATSM による腫瘍内がん幹細胞ニッチイメージングと内用放射線治療への応用2009
Author(s)
吉井幸恵, 清野泰, 脇厚生, 渡辺亮, 森哲也, 吉井裕, 古川高子, 浅井竜哉, 工藤崇, 岡沢秀彦, Michael J.Welch, 藤林靖久
Organizer
第4回日本分子イメージング学会
Place of Presentation
東京
Year and Date
20090514-20090515
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