2011 Fiscal Year Final Research Report
Development of survivin imaging agents for the realization of tumor specific nuclear medicine diagnosis
| Project/Area Number |
21791180
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Nagasaki University |
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Principal Investigator |
FUCHIGAMI Takeshi 長崎大学, 大学院・医歯薬学総合研究科, 助教 (30432206)
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| Project Period (FY) |
2009 – 2011
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| Keywords | Survivin / 放射性医薬品 / 核医学 / 腫瘍 |
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| Research Abstract |
In the present study, we aimed to develop survivin targeting radiopharmaceuticals for the realization of tumor specific nuclear medicine diagnosis. Because 4, 6-diaryl pyridinones have been reported to possess high affinity for dimer site of survivin protein, several derivatives were synthesized and evaluated. In the binding assay using the cancer cells with high expression of survivin, these 4, 6-diaryl pyridinone derivatives showed high membrane permeability and similar accumulation pattern with survivin expression site. Furthermore in vivo biodistribution study revealed that[^<125> I] 4, 6-diaryl pyridinones showed moderate blood retention and rapid clearance by normal tissues. The results of this study illustrate that these 4, 6-diaryl pyridinones might be promising tumor imaging agents for survivin.
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[Journal Article] Development of N-[^<11> C] methylamino 4-hydroxy-2(1H)-quinolone derivatives as PET radioligands for the glycine-binding site of NMDA receptors2009
Author(s)
T. Fuchigami, T. Haradahira, N. Fujimoto, Y. Nojiri, T. Mukai, F. Yamamoto, T. Okauchi, J. Maeda, K. Suzuki, T. Suhara, H. Yamaguchi, M. Ogawa, Y. Magata, M. Maeda
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Journal Title
Bioorg Med Chem.
Volume: 17
Pages: 5665-5675
Peer Reviewed
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[Presentation] Synthesis and preliminary evaluation of a C-11 labeled N-{ phenyl(piperidin-2-yl) methyl} benzamide derivative for visualization of glycine transporter 1 with PET2011
Author(s)
T. Fuchigami, A. Takano, Gulyas, Balazs, Jia Zhisheng, Finnema, Sjoerd, J., Andersson Jan D., Y. Magata, M. Haratake, M. Nakayama, and Halldin Christer
Organizer
The 19th International Symposium on Radiopharmaceutical Science
Place of Presentation
アムステルダム、オランダ
Year and Date
20110800
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