2010 Fiscal Year Final Research Report
Involvement of the microenvironment on the radiosensitivity
| Project/Area Number |
21791190
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Kyoto University |
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Principal Investigator |
KASHINO Genro Kyoto University, 原子炉実験所, 助教 (00437287)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 微小環境 |
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| Research Abstract |
It has been suggested that tumor microenvironment is important for the therapy. In this study, we examined the effects of secreted factors from irradiated cells on the treated cells to check the microenvironment after irradiation. The results suggest that membrane activity of mitochondria was reduced, and the level of reactive oxygen species was increased by the treatments of the secreted factors. Also, mutation fraction was increased in cells treated with secreted factors. However, these effects were not affected in radiosensitivity indicated by the foci formation of 53BP1 after X-irradiation.
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[Journal Article] Usefulness of hexamethylenetetramine as an adjuvant to radiation and cisplatin in the treatment of solid tumors : its independency of p53 status2010
Author(s)
Masunaga S, Tano K, Nakamura J, Watanabe M, Kashino G, Takahashi A, Tanaka H, Suzuki M, Ohnishi K, Kinashi Y, Liu Y, Ohnishi T, Ono K.
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Journal Title
J.Radiat.Res. 51
Pages: 27-35
Peer Reviewed
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[Journal Article] Influence of manipulating hypoxia in solid tumors on the radiation dose-rate effect in vivo, with reference to that in the quiescent cell population.2010
Author(s)
Masunaga S, Hirayama R, Uzawa A, Kashino G, Takata T, Tanaka H, Suzuki M, Kinashi Y, Liu Y, Koike S, Ando K, Ono K.
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Journal Title
Jap.J.Raiol. 28
Pages: 132-142
Peer Reviewed
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[Journal Article] Inductions of DNA double strand breaks and cellular migrations through the bystander effects in the cells irradiated with slit type microplanar beam of the SPring-8 synchrotron.2009
Author(s)
Kashino G, Kondoh T, Nariyama N, Umetani K, Ohigashi T, Shinohara K, Kurihara A, Fukumoto M, Tanaka H, Maruhashi A, Suzuki M, Kinashi Y, Liu Y, Masunaga S, Watanabe M, Ono K
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Journal Title
Int.J Radiat.Oncol.Biol.Physic. 74
Pages: 229-236
Peer Reviewed
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[Journal Article] Spectromicroscopic film dosimetry for high-energy microbeam from synchrotron radiation.2009
Author(s)
Nariyama N, Ohigashi T, Umetani K, Shinohara K, Tanaka H, Maruhashi A, Kashino G, Kurihara A, Kondob T, Fukumoto M, Ono K
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Journal Title
Appl.Radiat.Isot. 67
Pages: 155-159
Peer Reviewed
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[Journal Article] Usefulness of hexamethylenetetramine in combination with chemotherapy using free and pegylated liposomal doxorubicin in vivo, referring to the effect on quiescent cells2009
Author(s)
Masunaga S, Kono K, Nakamura J, Tano K, Yoshida H, Watanabe M, Kashino G, Suzuki M, Kinashi Y, Liu Y, Ono K.
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Journal Title
Oncol.Rep. 21
Pages: 1307-1312
Peer Reviewed
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[Journal Article] Impact of accelerator-based boron neutron capture therapy(AB-BNCT)on the treatment of multiple liver tumors and malignant pleural mesothelioma.2009
Author(s)
Suzuki M, Tanaka H, Sakurai Y, Kashino G, Yong L, Masunaga S, Kinashi Y, Mitsumoto T, Yajima S, Tsutsui H, Sato T, Maruhashi A, Ono K
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Journal Title
Radiother.Oncol. 92
Pages: 89-95
Peer Reviewed
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[Journal Article] A Simple and Rapid Method for Measurement of 10B-para-Boronophenylalanine in the Blood for Boron Neutron Capture Therapy Using Fluorescence Spectrophotometry.2009
Author(s)
Kashino G, Fukutani S, Suzuki M, Liu Y, Nagata K, Masunaga SI, Maruhashi A, Tanaka H, Sakurai Y, Kinashi Y, Fujii N, Ono K
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Journal Title
J.Radiat.Res. 50
Pages: 377-382
Peer Reviewed
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