2012 Fiscal Year Final Research Report
An attempt to optimize treatment strategy using a novel risk categorization of prostate cancer
| Project/Area Number |
21791192
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Osaka University |
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Principal Investigator |
YOSHIOKA Yasuo 大阪大学, 医学系研究科, 准教授 (30379242)
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| Project Period (FY) |
2009 – 2012
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| Keywords | 放射線治療 / 放射線腫瘍学 / 前立腺癌 / リスク分類 |
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| Research Abstract |
There are many options in radiotherapy for prostate cancer, including external beam radiotherapy (EBRT), low-dose-rate (LDR) or high-dose-rate (HDR) brachytherapy. However, it is still unclear which patient-group is suitable for which option or its optimal radiation dose. We developed an original risk-grouping method named PRIX (Prostate Cancer Risk Index). In EBRT, PRIX 0 group did not required radiation dose-escalation, while PRIX 1-6 needed it. In brachytherapy, both LDR and HDR showed good results in PRIX 0. HDR also showed satisfactory results in PRIX 1-6, which implied thatescalating the biological effective dose by hypofractionation was associated with better results. We are planning next clinical trials, including LDR brachytherapy for PRIX 1, stereotactic radiotherapy using CyberKnife, and hypofractionated intensity-modulated radiotherapy, based on these findings obtained by this study.
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[Journal Article] onotherapeutic high-dose-rate brachytherapy for prostate cancer: Five-year results of an extreme hypofractionation regimen with 54 Gy in nine fractions2011
Author(s)
Yoshioka Y, Konishi K, Sumida I, Takahashi Y, Isohashi F, Ogata T, Koizumi M, Yamazaki H, Nonomura N, Okuyama A, Inoue T
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Journal Title
Int J Radiat Oncol Biol Phys
Volume: 80
Pages: 469-475
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[Journal Article] External-beam radiotherapy for clinically localized prostate cancer in Osaka, Japan, 1995-2006: Time trends, outcome, and risk stratification2009
Author(s)
Yoshioka Y, Suzuki O, Kobayashi K, Teshima T, Yamada Y, Kotsuma T, Koizumi M, Kagawa K, Chatani M, Shimamoto S, Tanaka E, Yamazaki H, Inoue T
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Journal Title
Strahlenther Onkol
Volume: 185
Pages: 446-452
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