2010 Fiscal Year Final Research Report
Development of stabilized neuroreceptor concentration imaging method based on pattern recognition for kinetic analysis in PET
| Project/Area Number |
21791233
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Kitasato University (2010)
National Institute of Radiological Sciences (2009) |
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Principal Investigator |
SAKAGUCHI Kazuya Kitasato University, 医療衛生学部, 講師 (40521175)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 核医学 / PET / 薬物動態解析 / 神経受容体濃度測定 |
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| Research Abstract |
In neuroreceptor concentration measuring with PET, this study proposed developing a stabilized kinetic imaging algorithm which is based on a novel voxel-based kinetic parameter estimation method with high accuracy and high robustness. The proposed method estimated proportionality constant during transient equilibrium condition. The method restricted to reduce the number of data points, and it was not enough to use in clinical study. However, this study indicates that the method has an ability to improve using points of data from before equilibrium.
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[Journal Article] Imaging of I2-imidazoline receptors by small-animal PET using 2-(3-fluoro-[4-^<11>C]tolyl)-4,5-dihydro-1H-imidazole([^<11>C]FTIMD).2010
Author(s)
K.Kawamura, M.Naganawa, F.Konno, J.Yui, H.Wakizaka, T.Yamasaki, K.Yanamoto, A.Hatori, M.Takei, Y.Yoshida, K.Sakaguchi, T.Fukumura, Y.Kimura MR.Zhang.
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Journal Title
Nucl Med Biol Vol.37, No.5
Pages: 625-635
Peer Reviewed
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