2011 Fiscal Year Final Research Report
Effect of carbon-ion beams for highly metastatic potentials of mouse malignant melanomas
| Project/Area Number |
21791234
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
MATSUMOTO Yoshitaka 独立行政法人放射線医学総合研究所, 重粒子医科学センター, 研究員 (70510395)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 粒子線治療 |
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| Research Abstract |
In this study, the effects of the carbon-ion beam(C-ions) and photon beam to the cytotoxic affects and metastasis abilities of highly metastatic cancer were investigated using cell and animal experiments. C-ions showed superior effects to not only cell death but also inhibition of cell migration, invasion and adhesion abilities concerned with metastasis than photons. Additionally, the C-ions significantly suppressed the number of lung metastasis compared with photons in animal experiment, and the effect was remarkable even when compared with biological iso-effective dose on tumor cell survival. It was suggested that high-LET radiation, such as C-ions, would suppress the metastasis significantly compared with photon beams, such as a gamma ray and X-rays.
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