2010 Fiscal Year Final Research Report
Development of in-vivo dosimetry for proton beam therapy and application to a precise proton beam treatment plan
| Project/Area Number |
21791236
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East |
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Principal Investigator |
KOHNO Ryosuke 独立行政法人国立がん研究センター, 臨床開発センター, 研究員 (20392227)
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| Co-Investigator(Renkei-kenkyūsha) |
HOTTA Kenji 筑波大学, 数理物質科学研究科, 大学院生
MATSUBARA Kana 首都大学東京, 人間健康科学研究科, 大学院生
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| Project Period (FY) |
2009 – 2010
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| Keywords | 陽子線治療 / 体内線量測定 / ペンシルビーム線量計算法 / 高速モンテカルロ法 / MOSFET検出器 / LET依存性 |
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| Research Abstract |
To perform in-vivo dosimetry in the proton beam therapy, I developed a dose calculation algorithm which can calculate precisely even in tissue heterogeneity. I tried the use of the metal oxide-silicon semiconductor field effect transistor (MOSFET) detector as a radiation detector for in-vivo dosimetry and improved sensitivity deterioration of the MOSFET detector for linear energy transfer (LET) effects. Furthermore, a correction method for sensitivity deterioration of the MOSFET detector was developed, and the proton dose measurements with the MOSFET detector by the correction method was established.
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