2010 Fiscal Year Final Research Report

Developing a novel therapy targeting graft inflammation in pediatric organ transplantation.

Research Project

Project/Area Number	21791241
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	General surgery
Research Institution	University of Tsukuba
Principal Investigator	FUJISHIRO Jun University of Tsukuba, 大学院・人間総合科学研究科, 講師 (60528438)
Project Period (FY)	2009 – 2010
Keywords	虚血再潅流障害 / グラフト炎症 / 免疫抑制剤 / 拒絶反応 / 臓器保存
Research Abstract	Graft manipulation, ischemia/reperfusion injury and acute rejection all initiate a severe cellular and molecular inflammation in graft organ, which would impair short- and long-term graft function. In this study, I showed that 1) non-specific and T cell mediated inflammation process occurred in graft muscle layer just after reperfusion in rat small bowel transplantation, tacrolimus and sirolimus both reduced above-mentioned complex inflammation and improved graft motility and 2)long-acting erythropoietion analog darbepoetion had promising organ-protecting effect in rat liver ischemia/reperfusion injury model.