Relationship between cancer stem cells and bone marrow derived cells in esophageal and gastric cancer

2010 Fiscal Year Final Research Report

• Project/Area Number: 21791274
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Digestive surgery
• Research Institution: University of Toyama
• Principal Investigator: OKUMURA Tomoyuki University of Toyama, 大学院・医学薬学研究部, 助教 (10533523)
• Project Period (FY): 2009 – 2010
• Keywords: 胃癌 / 食道癌 / 幹細胞 / 骨髄

Research Abstract

interaction between cancer stem cells and mesenchymal cells in esophageal and gastric cancer

Research Products

• [Journal Article] K-ras mutation targeted to gastric tissue progenitor cells results in chronic inflammation, an altered microenvironment, and progression to intraepithelial neoplasia. (2010)
  • Author(s): Okumura T, Ericksen RE, Takaishi S, Wang SS, Dubeykovskiy Z, Shibata W, Betz KS, Muthupalani S, Rogers AB, Fox JG, Rustgi AK, Wang TC.
  • Journal Title: Cancer Research 70(21) Pages: 8435-8445
  • Peer Reviewed
• [Journal Article] Identification of a bone marrow-derived mesenchymal progenitor cell subset that can contribute to the gastric epithelium. (2009)
  • Author(s): Okumura T, Wang SW, Takaishi S, Tu S, Ericksen R, Rustgi AK, Wang TC
  • Journal Title: Laboratory Investigation 89(12) Pages: 1410-1422
  • Peer Reviewed
• [Journal Article] Fibroblastic colony-forming unit bone marrow cells delay progression to gastric dysplasia in a helicobacter model of gastric tumorigenesis. (2009)
  • Author(s): Wang SS, Asfaha S, Okumura T, Betz KS, Muthupalani S, Rogers AB, Tu S, Takaishi S, Jin G, Yang X, Wu DC, Fox JG, Wang TC.
  • Journal Title: Stem Cells. 27(9) Pages: 2301-2311
  • Peer Reviewed
• [Journal Article] Identification of gastric cancer stem cells using the cell surface marker CD44 (2009)
  • Author(s): Takaishi S, Okumura T, Tu S, Wang SW, Shibata W, Vigneshwaran R, Gordon AK S, Shimada Y, Wang TC
  • Journal Title: Stem Cells. 27 Pages: 1006-1020
  • Peer Reviewed
• [Presentation] Identification of aldehyde dehydrogenase (ALDH) -1/CD44 double positive cells in gastric cancer. (2011)
  • Author(s): Tomoyuki Okumura, Yutaka Shimada, Soshi Osawa, Shinich Sekine, Ryota Hori, T Omura, Makoto Moriyama, Koshi Matsui, Isaku Yoshioka, Syojo Hojyo, Shigeaki Sawada, Toru Yoshida, Takuya Nagata Hideyuki Uotani, Junya Hukuoka, Kazuhiro Tsukada
  • Organizer: The 9th International Gastric Cancer Congress
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2011-04-22
• [Presentation] 胃癌組織における幹細胞マーカーCD44およびALDH-1の発現 (2011)
  • Author(s): 奥村知之、嶋田裕、大澤宗士、関根慎一、堀亮太、大村哲也、森山亮仁、松井恒志、吉岡伊作、澤田成朗、吉田徹、長田拓哉、魚谷英之、福岡順也、塚田一博
  • Organizer: 第83回日本胃癌学会総会
  • Place of Presentation: 青森県三沢市
  • Year and Date: 2011-03-05
• [Presentation] k19-krasマウス胃癌モデルにおけるDCAMKL-1およびLGR-5発現細胞の役割 (2011)
  • Author(s): 奥村知之、嶋田裕、Russell Ericksen、Sophie Wang、高石繁雄、Timothy Wang、塚田一博
  • Organizer: 第83回日本胃癌学会総会
  • Place of Presentation: 青森県三沢市
  • Year and Date: 2011-03-05
• [Presentation] 低親和性神経成長因子受容体(p75NTR)を標的とした食道癌治療の可能性 (2010)
  • Author(s): 奥村知之、嶋田裕、大澤宗士、関根慎一、神山公希、堀亮太、澤田成明、吉田徹、長田拓哉、魚谷英之、塚田一博
  • Organizer: 第21回日本消化器癌発生学会総会
  • Place of Presentation: 軽井沢
  • Year and Date: 2010-11-18
• [Presentation] 胃癌におけるALDH-1の発現とその意義 (2010)
  • Author(s): 奥村知之、嶋田裕、大澤宗士、関根慎一、澤田成朗、長田拓哉、福岡順也、塚田一博
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-22
• [Presentation] Expression of miRNAs in p75NTR positive esophageal squamous cell carcinoma (2010)
  • Author(s): TomoyukiOkumura, Yutaka Shimada, Soshi Osawa, ShinichiSekine, Makoto Moriyama, Kazuhiro Tsukada
  • Organizer: The 12th World Congress of the International Society for Diseases of Esophagus
  • Place of Presentation: Kagoshima, Japan
  • Year and Date: 2010-09-04
• [Presentation] p75NTR陽性食道扁平上皮癌細胞で発現しているmicro-RNAの探索 (2010)
  • Author(s): 奥村知之、嶋田裕、大澤宗士、関根慎一、吉岡伊作、澤田成朗、吉田徹、長田拓哉、塚田一博
  • Organizer: 第65回日本消化器外科学会総会
  • Place of Presentation: 下関
  • Year and Date: 2010-07-14