2010 Fiscal Year Final Research Report
Mechanism of recurrence in hepatocel lular carcinoma after livertransplantation
| Project/Area Number |
21791292
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | The University of Tokushima |
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Principal Investigator |
IMURA Satoru The University of Tokushima, 病院, 助教 (90380021)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMADA Mitsuo 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (10216070)
MORINE Yuji 徳島大学, 病院, 助教 (60398021)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 肝臓外科学 |
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| Research Abstract |
The aim of this study was to clarify the mechanism of liver metastasis after liver transplantation. Splenic injection model was used as micrometastasis setting via portal vein. Macroscopic metastasis was observed in all mice, but IFN administration significantly decreased number of liver metastasis (19.3 versus 6.0, p<0.05). Microvessel density was quantified using CD34 immunostaining and IFN significantly suppressed angiogenesis compared with control. Expression of adhesion molecules such as VCAM and ICAM did not correlate with IFN treatment.
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