2010 Fiscal Year Final Research Report
The experimental research on the artificial bioabsorbable trachea
| Project/Area Number |
21791327
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | Kagawa University |
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Principal Investigator |
CHANG Sunsoo Kagawa University, 医学部附属病院, 助教 (00419508)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 気管軟骨 / b-FGF / BMP-2 / 組織再生 / 生体吸収性材料 |
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| Research Abstract |
The purpose of this research is a replacement of canine cervical trachea by the artificial bioabsorbable trachea with slow releasing cell growth factor. Optimum dose of cell growth factor (b-FGF : basic fibroblast growth factor, BMP-2 : bone morphogenetic protein) was 100μg, respectively. Two-third of the cervical trachea replacement model with the use of a bioabsorbable poly-L-lactic acid and ε-caprolactone copolymer (PLAC) scaffold and slow releasing cell growth factor survived for 4 weeks without marked airway stenosis, cartilage regeneration was not revealed histologically.
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