2011 Fiscal Year Final Research Report
Vagal denervation in the surgery for atrial fibrillation : Identification of cardiac autonomic nerural network
| Project/Area Number |
21791335
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 心臓神経叢 / 心房細動手術 |
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| Research Abstract |
High frequency stimulation was applied to 5 anatomical ganglionated plexi(GP) areas, a total of 35 sites to identify the active GP with marked vagal reflex(prolongation of ventricular interval by more than 50%). Active GP was observed in the right pulmonary vein, left pulmonary vein, inferior left atrium and left atrial roof. Right pulmonary vein is the most frequent seen active GP area. Epicardial ablation of active GP provided complete vagal denervation in terms of eliminating electrical activities in the whole atrium and additional endocardial ablation for the remaining network was not required. Sequential pacing and ablation technique identify the epicardial GP network with a dominant active GP. The GP in the inferior left atrium was the most dominant active GP in the atrium. Active GP in the medial-cranial and medial-caudal area was more comparatively dominant than lateral area in the network.
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