2010 Fiscal Year Final Research Report
Gene expression profiles associated with neurocognitive decline after aortic surgery under deep hypothermic circulatory arrest.
| Project/Area Number |
21791337
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | Osaka Medical College |
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Principal Investigator |
MIENO Shigetoshi Osaka Medical College, 医学部, 助教 (10411373)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 心臓大血管外科 |
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| Research Abstract |
This study was examined incidence of temporary neurocognitive decline (NCD) and change in gene expression associated with NCD after aortic surgery utilizing deep hypothermic circulatory arrest. Neurocognitive decline (NCD) occurred at 60% after the aortic surgery. The change in gene expression between pre-and post-operative blood sample was compared by microarray analysis. Change in the gene expression involved in inflammatory and immune responses was associated with NCD after aortic surgery utilizing deep hypothermic circulatory arrest.
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