2010 Fiscal Year Final Research Report

Expression of cellular protective factors in neuronal cells after cerebral ischemia

Research Project

Project/Area Number	21791344
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Cerebral neurosurgery
Research Institution	Tohoku University
Principal Investigator	SAITO Atsushi Tohoku University, 大学院・医学系研究科, 非常勤講師 (60375053)
Project Period (FY)	2009 – 2010
Keywords	実験脳外科学
Research Abstract	We focused on pathophysiological states of carotid atherosclerotic lesion as one of targets of cerebral ischemia. Our purposes were first, evaluation of expression of lectin-like low density lipoprotein receptor 1 (LOX1) in rat carotid plaque, second, establishment of targeting drug delivery system for carotid atherosclerotic lesion using LOX1. Liposomal fasudil conjugated with anti-LOX1 antibody on the surface was newly developed and selective accumulation of the new drug and effectiveness on inhibition of abrogation of carotid plaque. The new liposomal fasudil was specifically accumulated on the carotid lesion and plaque extension was significantly inhibited after intravenous administration of liposomal fasudil with LOX1 antibody.