Molecular mechanisms associated with 1p 19q loss of heterozygosity in oligodendroglioma

2010 Fiscal Year Final Research Report

• Project/Area Number: 21791347
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Cerebral neurosurgery
• Research Institution: Saitama Medical University (2010); The University of Tokyo (2009)
• Principal Investigator: KOGA Tomoyuki 埼玉医科大学, 医学部, 助教 (40456124)
• Project Period (FY): 2009 – 2010
• Keywords: 脳腫瘍 / 乏突起神経膠腫 / 染色体異常 / MYT1L

Research Abstract

Oligodendrogliomas with 1p19q loss of heterozygosity respond well to chemotherapy compared with those without. However, the molecular mechanisms associated with this chromosomal abnormality are not well known. Based on the results of our previous study, we have targeted a transcriptional factor, myelin transcription factor 1-like (MYT1L). We have performed RT-PCR. Expression level of MYT1L was higher in oligodendrogliomas with 1p19q loss of heterozygosity. These results suggested that the expression of MYT1L is associated with chromosomal change in oligodendrogliomas and possibly useful as diagnostic tool of these tumors.

Research Products

• [Journal Article] Contribution of technological progress, inter-operator difference and experience of operators in gamma knife radiosurgery for arteriovenous malformation (2011)
  • Author(s): Koga T, Shin M, Maruyama K, Kurita H, Kawamoto S, Saito N.
  • Journal Title: Acta Neurochir (Wien) Volume: 153 Pages: 879-882
  • Peer Reviewed
• [Journal Article] Outcomes of radiosurgery for brain stem arteriovenous malformations. (2011)
  • Author(s): Koga T, Shin M, Terahara A, Saito N.
  • Journal Title: Neurosurgery Volume: 69 Pages: 45-52
  • Peer Reviewed
• [Journal Article] Treatment with high marginal dose is mandatory to achieve long-term control of skull base chordomas and chondrosarcomas by means of stereotactic radiosurgery. (2010)
  • Author(s): Koga T, Shin M, Saito N.
  • Journal Title: J Neurooncol Volume: 98 Pages: 233-238
  • Peer Reviewed
• [Journal Article] Long-term outcomes of stereotactic radiosurgery for arteriovenous malformations in the thalamus. (2010)
  • Author(s): Koga T, Shin M, Maruyama K, Terahara A, Saito N.
  • Journal Title: Neurosurgery Volume: 67 Pages: 398-403
  • Peer Reviewed
• [Journal Article] Role of gamma knife radiosurgery in neurosurgery: past and future perspectives. (2010)
  • Author(s): Koga T, Shin M, Saito N.
  • Journal Title: Neurol Med Chir (Tokyo) Volume: 50(9) Pages: 737-749
  • Peer Reviewed
• [Journal Article] Contrast-enhanced magnetic resonance characteristics of arteriovenous malformations after gamma knife radiosurgery: predictors of post-angiographic obliteration. (2010)
  • Author(s): Kunishima K, Shin M, Kunimatsu A, Aoki S, Sasaki H, Koga T, Itoh D, Mori H, Abe O, Ohtomo K, Saito N.
  • Journal Title: Neurosurgery Volume: 67 Pages: 100-109
  • Peer Reviewed
• [Journal Article] The value of image coregistration during stereotactic radiosurgery. (2009)
  • Author(s): Koga T, Maruyama K, Igaki H, Tago M, Saito N.
  • Journal Title: Acta Neurochir (Wien) Volume: 151 Pages: 465-471
  • Peer Reviewed
• [Journal Article] Long-term control of disseminated pleomorphic xanthoastrocytoma with anaplastic features by means of stereotactic irradiation. (2009)
  • Author(s): Koga T, Morita A, Maruyama K, Tanaka M, Ino Y, Shibahara J, Louis DN, Reifenberger G, Itami J, Hara R, Saito N, Todo T.
  • Journal Title: Neuro-Oncol Volume: 11 Pages: 446-451
  • Peer Reviewed
• [Journal Article] Arcuate fasciculus tractography integrated into gamma knife surgery. (2009)
  • Author(s): Maruyama K, Koga T, Kamada K, Ota T, Itoh D, Ino K, Igaki H, Aoki S Masutani Y, Shin M, Saito N.
  • Journal Title: J Neurosurg Volume: 111 Pages: 520-526
  • Peer Reviewed
• [Journal Article] Assessment of arteriovenous malformations with 3-Tesla time-resolved, cibtrast-enhanced, three-dimensional magnetic resonance angiography. (2009)
  • Author(s): Kunishima K, Mori H, Itoh D, Aoki S, Kabasawa H, Koga T, Maruyama K, Masumoto T, Abe O, Ohtomo K.
  • Journal Title: J Neurosurg Volume: 110 Pages: 492-499
  • Peer Reviewed
• [Journal Article] Stereotactic radiosurgery for skull base meningioma. (2009)
  • Author(s): Igaki H, Maruyama K, Koga T, Murakami N, Tago M, Terahara A, Shin M, Nakagawa K, Ohtomo K.
  • Journal Title: Neurol Med Chir (Tokyo) Volume: 49 Pages: 456-461
  • Peer Reviewed
• [Journal Article] Extended field stereotactic radiosurgery for recurrent glioblastoma
  • Author(s): Koga T, Maruyama K, Tanaka M, Ino Y, Saito N, Nakagawa K, Shibahara J, Todo T.
  • Journal Title: Cancer Volume: (in press)
  • Peer Reviewed
• [Journal Article] Integration of corticospinal tractography reduces motor complication after radiosurgery
  • Author(s): Koga T, Shin M, Maruyama K, Kamada K, Ota T, Itoh D, Kunii N, Ino K, Aoki S, Masutani Y, Igaki H, Onoe T, Saito N.
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: (in press)
  • Peer Reviewed
• [Journal Article] Outcomes of diffusion-tensor tractography integrated stereotactic radiosurgery
  • Author(s): Koga T, Maruyama K, Kamada K, Ota T, Shin M, Itoh D, Kunii N, Ino K, Terahara A, Aoki S, Masutani Y, Saito N.
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: (in press)
  • Peer Reviewed
• [Journal Article] Delayed complication after gamma knife radiosurgery for mesial temporal lobe epilepsy
  • Author(s): Usami K, Kawai K, Koga T, ShinM, Kurita H, Suzuki I, Saito N.
  • Journal Title: J Neurosurg Volume: (in press)
  • Peer Reviewed
• [Presentation] 再発神経膠芽腫の長期腫瘍制御をめざした定位放射線治療の照射や拡大の効果 (2011)
  • Author(s): 甲賀智之, 藤堂具紀, 花北俊哉, 辛正廣, 丸山啓介, 武笠晃丈, 齊藤邦昭, 斉藤延人
  • Organizer: 社団法人日本脳神経外科学会総会第70 回学術総会
  • Place of Presentation: パシフィコ横浜, (特別シンポジウム)
  • Year and Date: 20111012-14
• [Presentation] Comparison of outcomes after brain radiosurgery with and without use of diffusion-tensor tractography (2011)
  • Author(s): Koga T, Shin M, Hanakita S, Kunii N, Ino K, Masutani Y, Saito N.
  • Organizer: Tenth biennial congress and exhibition of the international stereotactic radiosurgery society
  • Place of Presentation: Paris, France
  • Year and Date: 20110508-12
• [Presentation] 拡散テンソルトラクトグラフィ合成によるガンマナイフ治療の安全性の向上 (2011)
  • Author(s): 甲賀智之, 丸山啓介, 辛正廣, 鎌田恭輔, 國井尚人, 斉藤延人
  • Organizer: 第34 回日本脳神経CI 学会総会
  • Place of Presentation: 米子コンベンションセンター(鳥取)
  • Year and Date: 20110204-05
• [Presentation] Contribution of technological progress and influence of inter-operator difference in gamma knife radiosurgery for arteriovenous malformation. (2010)
  • Author(s): Koga T, Shin M, Saito N.
  • Organizer: Leksell Gamma Knife Society 2010 Meeting
  • Place of Presentation: Nagoya Congress Center
  • Year and Date: 20101111-13
• [Presentation] Preventing morbidity of gamma knife radiosurgery by integrating tractography. (2010)
  • Author(s): Koga T, Shin M, Maruyama K, Saito N.
  • Organizer: Asian Leksell Gamma Knife Society 2010 Meeting
  • Place of Presentation: Nagoya, Japan, (Symposium)
  • Year and Date: 20101111-13
• [Presentation] さらなる低侵襲化をめざした脳動静脈奇形に対する定位放射線療法, 最新の試み (2010)
  • Author(s): 甲賀智之, 辛正廣, 丸山啓介, 金太一, 斉藤延人
  • Organizer: 社団法人日本脳神経外科学会総会第69 回学術総会
  • Place of Presentation: 福岡国際会議場, (シンポジウム)
  • Year and Date: 20101027-29
• [Presentation] Spetzler-Martin Grading による脳動静脈奇形に対する定位放射線治療と摘出術の治療成績の比較 (2010)
  • Author(s): 甲賀智之, 辛正廣, 斉藤延人
  • Organizer: 第25 回日本脳神経外科国際学会フォーラム
  • Place of Presentation: 大宮ソニックシティー(埼玉), (教育講演)
  • Year and Date: 20100723-24
• [Presentation] Characteristics of central nervous system germinoma involving the basal ganglia: a literature review. (2010)
  • Author(s): Koga T, Matsutani M.
  • Organizer: 14th International Symposium on Pediatric Neuro-Oncology
  • Place of Presentation: Vienna, Austria
  • Year and Date: 20100620-23
• [Presentation] 脳動静脈奇形に対する定位放射線治療の治療予後を予測するためのグレーディングシステムの提唱 (2010)
  • Author(s): 甲賀智之, 辛正廣, 寺原敦朗, 斉藤延人
  • Organizer: 第39回日本脳卒中の外科学会
  • Place of Presentation: 岩手県民会館, (シンポジウム)
  • Year and Date: 20100415-17
• [Presentation] 脊索腫に対する定位放射線外科治療の役割 (2010)
  • Author(s): 甲賀智之, 辛正廣, 斉藤延人
  • Organizer: 第28 回日本脳腫瘍学会学術集会
  • Place of Presentation: 軽井沢
  • Year and Date: 2010-11-29
• [Presentation] 巨大脳動静脈奇形に対する多段階放射線治療の役割 (2010)
  • Author(s): 甲賀智之, 辛正廣, 丸山啓介, 井垣浩, 斉藤延人
  • Organizer: 第19 回定位放射線治療学会
  • Place of Presentation: ピアザ淡海(滋賀県)
  • Year and Date: 2010-07-30
• [Presentation] Outcomes of stereotactic radiosurgery for intracanalicular vestibular schwannomas. (2010)
  • Author(s): Koga T, Shin M, Saito N.
  • Organizer: 7th Meeting of Asian Society for Neuro-Oncology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2010-06-12
• [Presentation] 照射野を拡大した定位放射線外科治療による再発膠芽腫の局所制御 (2009)
  • Author(s): 甲賀智之, 藤堂具紀, 稲生靖, 田中実, 武笠晃丈, 寺原敦朗, 斉藤延人
  • Organizer: 第27 回日本脳腫瘍学会
  • Place of Presentation: 全日空ゲートタワーホテル大阪
  • Year and Date: 20091108-10
• [Presentation] Outcomes of stereotactic radiosurgery for skull base meningiomas. (2009)
  • Author(s): Koga T, Shin M, Saito N.
  • Organizer: 2009 joint meeting of the society for neuro-oncology and the AANS/CNS section on tumors
  • Place of Presentation: New Orleans, Louisiana, USA
  • Year and Date: 20091022-24
• [Presentation] 脳動静脈奇形に対する定位的放射線療法の長期治療成績に基づいた治療戦略の展望 (2009)
  • Author(s): 甲賀智之, 辛正廣, 丸山啓介, 寺原敦朗, 斉藤延人
  • Organizer: 第68 回日本脳神経外科学会総会
  • Place of Presentation: 京王プラザホテル(東京), (シンポジウム)
  • Year and Date: 20091014-16
• [Presentation] 頭蓋底髄膜腫に対するガンマナイフの治療成績 (2009)
  • Author(s): 甲賀智之, 辛 正廣, 斉藤延人
  • Organizer: 第21 回日本頭蓋底外科学会
  • Place of Presentation: アクロス福岡, (シンポジウム)
  • Year and Date: 20090702-03
• [Presentation] Treatment with high marginal dose is mandatory to achieve long-term control of skull base chordomas and chondrosarcomas by means of stereotactic radiosurgery. (2009)
  • Author(s): Koga T, Shin M, Saito N.
  • Organizer: Ninth biennial congress and exhibition of the international stereotactic radiosurgery society
  • Place of Presentation: Seoul, Korea
  • Year and Date: 20090607-11
• [Presentation] Long-term outcomes of stereotactic radiosurgery for cerebral arteriovenous malformations of each Spetzler-Martin Grade: Comparison with surgical outcomes. (2009)
  • Author(s): Koga T, Shin M, Maruyama K, Igaki H, Saito N.
  • Organizer: Ninth biennial congress and exhibition of the international stereotactic radiosurgery society
  • Place of Presentation: Seoul, Korea
  • Year and Date: 20090607-11
• [Presentation] Treatment with high marginal dose is mandatory to achieve long-term control of skull base chordomas and chondrosarcomas by means of stereotactic radiosurgery. (2009)
  • Author(s): Koga T, Shin M, Saito N.
  • Organizer: The third quadrennial meeting of the world federation of neuro-oncology
  • Place of Presentation: Pacifico Yokohama
  • Year and Date: 20090511-14
• [Presentation] Spetzler-Martin grading による脳動静脈奇形に対する定位放射線治療と摘出術の治療成績の比較 (2009)
  • Author(s): 甲賀智之, 辛 正廣, 斉藤延人
  • Organizer: 第38 回日本脳卒中の外科学会
  • Place of Presentation: 島根県民会館, (シンポジウム)
  • Year and Date: 20090321-22
• [Presentation] 視床下部過誤腫治療後に残存する難治性非笑い発作の病態と外科治療 (2009)
  • Author(s): 甲賀智之, 川合謙介, 鎌田恭輔, 太田貴裕, 宇佐美憲一, 斉藤延人
  • Organizer: 第32 回日本てんかん外科学会
  • Place of Presentation: 東京ステーションコンファレンス
  • Year and Date: 20090122-23
• [Presentation] 播種を来したpleomorphic xanthoastrocytomawith anaplastic features に対する定位放射線治療による腫瘍制御 (2009)
  • Author(s): 甲賀智之, 辛正廣, 丸山啓介, 藤堂具紀, 斉藤延人
  • Organizer: 第18 回日本定位放射線治療学会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2009-07-17
• [Presentation] 定位放射線治療による脳動静脈奇形のナイダス閉塞後にみられる長期合併症 (2009)
  • Author(s): 甲賀智之, 辛正廣, 丸山啓介, 寺原敦朗, 斉藤延人
  • Organizer: 第18 回日本定位放射線治療学会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2009-07-17
• [Presentation] 頭蓋底髄膜腫に対するガンマナイ フの治療成績 (2009)
  • Author(s): 甲賀智之, 辛 正廣, 斉藤延人
  • Organizer: 第18 回日本定位放射線治療学会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2009-07-17
• [Presentation] Long-term outcomes of stereotactic radiosurgery for arteriovenous malformations in the thalamus. (2009)
  • Author(s): Koga T, Shin M, Maruyama K, Terahara A, Saito N.
  • Organizer: First Asia Leksell Gamma Knife Society meeting
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2009-06-09
• [Presentation] 高齢者における髄膜腫に対する radiosurgery の治療成績 (2009)
  • Author(s): 甲賀智之, 辛 正廣, 斉藤延人
  • Organizer: 第22 回日本老年脳経外科学会
  • Place of Presentation: 広島大学, (シンポジウム)
  • Year and Date: 2009-03-27