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2011 Fiscal Year Final Research Report

The induction of autophagy in malignant glioma cells treated with natural compound

Research Project

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Project/Area Number 21791349
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionNiigata University

Principal Investigator

AOKI Hiroshi  新潟大学, 医歯学総合病院, 特任助教 (30515771)

Project Period (FY) 2009 – 2011
KeywordsNF-kB / オートファジー / クルクミン / テモゾロマイド / 天然化合物 / 悪性神経膠腫 / 薬剤耐性
Research Abstract

Curcumin has high anticancer efficacy in vitro and in vivo by down-regulation of NF-kB, followed by induction of autophagy and autophagy. Targeting Autophagy through down-regulation of NF-kB is a new treatment strategy in patients with malignant glioma.

  • Research Products

    (9 results)

All 2011 2010 2009

All Journal Article (1 results) Presentation (8 results)

  • [Journal Article] Induction of autophagy in temozolomide treated malignant gliomas2011

    • Author(s)
      Natsumeda M, Aoki H, Miyahara H, Yajima N, Uzuka T, Toyoshima Y, Kakita A, Takahashi H, Fujii Y
    • Journal Title

      Neuropathology

      Volume: 31(5) Pages: 486-93

    • DOI

      doi:10.1111/j.1440-1789.2010.01197.x.

  • [Presentation] 悪性神経膠腫におけるAutophagyの役割2011

    • Author(s)
      青木洋、岡田正康、小倉良介、小林勉、藤井幸彦
    • Organizer
      第12回分子脳神経外科学会
    • Year and Date
      20110000
  • [Presentation] Autophagy2010

    • Author(s)
      青木洋
    • Organizer
      脳神経研究会
    • Year and Date
      20100000
  • [Presentation] Monitoring autophagy in malignant glioma with antibody against LC3B2010

    • Author(s)
      Hiroshi Aoki, Manabu Natsumeda, Seiji Kondo, Yukihiko Fujii
    • Organizer
      69th Annual Meeting of the Japanese Cancer Association
    • Year and Date
      20100000
  • [Presentation] LC3B抗体を用いた悪性グリオーマのオートファジーモニタリング2010

    • Author(s)
      Hiroshi Aoki, Manabu Natsumeda, Seiji Kondo, Yukihiko Fujii
    • Organizer
      The 11th Annual Meeting of the Japan Society for Molecular Neurosurgery
    • Year and Date
      20100000
  • [Presentation] オートファジー阻害薬を用いた新たな悪性グリオーマ治療の展開2009

    • Author(s)
      青木洋,篠島直樹,近藤靖子,近藤精二,藤井幸彦
    • Organizer
      第10回分子脳神経外科学会
    • Year and Date
      20090000
  • [Presentation] オートファジーの役割に注目したテモゾロミド併用薬の検討2009

    • Author(s)
      Hiroshi Aoki, Naoki Shinojima, Yasuko Kondo, Seiji Kondo, Yukihiko Fujii
    • Organizer
      The 27th Annual Meeting of the Japan Society for Neuro-Oncology
    • Year and Date
      20090000
  • [Presentation] INHIBITION OF TEMOZOLOMIDE-INDUCED AUTOPHAGY ENHANCES THE CYTOTOXIC EFFECT ON MALIGNANT GLIOMAS2009

    • Author(s)
      Hiroshi Aoki, Naoki Shinojima, Yasuko Kondo, Seiji Kondo, Yukihiko Fujii
    • Organizer
      The 68th Annual Meeting of the Japanese Cancer Association
    • Year and Date
      20090000
  • [Presentation] Selective H^+-ATPase inhibitor prevents the completion of autophagy induced by Temozolomide and emphasizes cytotoxicity in glioma cells2009

    • Author(s)
      Hiroshi Aoki, Naoki Shinojima, Yasuko Kondo, Seiji Kondo, Yukihiko Fujii
    • Organizer
      The 3rd Quadrennial Meeting of the World Federation of Neuro-Oncology
    • Year and Date
      20090000

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Published: 2013-07-31  

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