2011 Fiscal Year Final Research Report
The monitoring of autophagy in human brain tumor samples and pathological analysis
| Project/Area Number |
21791350
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | オートファジー / 神経膠腫 / テモゾロミド / 抗LC3B抗体 / 免疫染色法 / Western blot法 |
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| Research Abstract |
The induction of autophagy is effectively monitored in glioma cell cultures. However, the monitoring of autophagy in gliomas has not been established in surgically removed tissues. A new method to monitor autophagy in surgically removed brain tumor tissue employing immunohistochemistry and Western blotting was established, and induction of autophagy was detected after temozolomide treatment.
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