2010 Fiscal Year Final Research Report
Cytogenetic analysis and classification of medulloblastoma
| Project/Area Number |
21791351
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kanazawa University |
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Principal Investigator |
MISAKI Koichi Kanazawa University, 附属病院, 助教 (20507082)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 髄芽腫 / 分子遺伝学 / 病理学 / catenin / Wnt pathway |
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| Research Abstract |
We performed pathological classification of primary medulloblastomas and examined molecules on the Wnt signal pathway by immunohistochemical and cytogenetic analyses. Pathologically, three patients were diagnosed with newly established subtype of medulloblastoma. Immunohistochemical cyclin D1 expression showed a trend of adverse outcome and all seven patients with cyclin D1 expression expired. On the contrary, γ-catenin expression correlated with good prognosis among the molecules analyzed. This research contributed to prognostic evaluation of medulloblastomas.
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