2010 Fiscal Year Final Research Report
MR imaging of HER-2 in CNS tumors using Affibody
| Project/Area Number |
21791359
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Osaka University |
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Principal Investigator |
KINOSHITA Manabu Osaka University, 医学系研究科, 助教 (40448064)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 分子イメージング / MRI / Affibody / SPIO / HER-2 |
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| Research Abstract |
Detecting HER-2 expression is clinically relevant, as treatment methods and prognosis differ according to HER-2 expression status. In this study, we have focused on a small molecule named Affibody, which is one-tenth in molecular size of an antibody, possessing equal capability. SPIO was labeled to Affbody for MRI detection. When HER-2 overexpressing tumor (SKOV-3 ovarian cancer cell line) was inoculated to a SCID mouse, Affibody-SPIO successfully imaged HER-2 receptor on MRI. Accumulation of Affibody and SPIO was confirmed on histology.
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[Journal Article] Effects of concomitant temozolomide and radiation therapies on WT1-specific T cells in malignant glioma.2010
Author(s)
Chiba Y, Hashimoto N, Tsuboi A, Oka Y, Maruo A, Kinoshita M, Kagawa N, Oji Y, Hosen N, Nishida S, Sugiyama H, Yoshimine T.
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Journal Title
Jpn J Clin Oncol. 40(5)
Pages: 395-403
Peer Reviewed
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[Journal Article] A survey of disclosure of diagnosis to patients with glioma in Japan.
Author(s)
Yamamoto F, Hashimoto N, Kagawa N, Okita Y, Chiba Y, Kijima N, Kinoshita M, Yoshizu K, Fujimoto Y, Hirai K, Yoshimine T.
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Journal Title
Int J Clin Oncol. in press
Peer Reviewed
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