2010 Fiscal Year Final Research Report
Effects of mesenchymal stem cell on microenvironment of brain tumor
| Project/Area Number |
21791367
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kyushu University |
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Principal Investigator |
中溝 玲 Kyushu University, 大学院・医学研究院, 講師 (80529800)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 間葉系幹細胞 |
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| Research Abstract |
We proved that human mesenchymal stem cells accelerate the growth of human glioma cells (U87 cells) by cell-cell contact or unverified liquid factor. The level of VEGF、 bFGF、 TGFβ1、 MMP1、 MMP2、 MMP3、 MMP9、 MMP13、 MMP1、 IL-1β、 IL-8、 IL-10、 IL-13、 CCL3、 CCL-4、 CCL-5 in the supernatant obtained from the co-culture system were measured ELISA assay. We proved that the secretion of MMP2 and MMP3 from human glioma cells are inhibited by the presence of human mesenchymal stem cells in a dose-dependent manner.
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Research Products
(1 results)
