2010 Fiscal Year Final Research Report
Identification of the mechanism of self-proliferation in brain tumor stem cells
| Project/Area Number |
21791369
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kyushu University |
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Principal Investigator |
MATSUMOTO KENICHI Kyushu University, 医学研究院, 研究員 (80423581)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 脳腫瘍学 |
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| Research Abstract |
To dissect the biological mechanism of the self-proliferation in glioma stem cell, we first tried to establish the glioma cell lines with stem cell activity. We removed the glioma tissues from the patients and performed primary culture of these cells with EGF and EGF in serum free conditon. So far, we have established four cell lines which continue to proliferate more than 10 passages. Since we have not proved the stem cell potential of these cells, the mechanism of the self-proliferation have not been identified.
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