2011 Fiscal Year Final Research Report
Control of intracellular signaling, involved in neuronal differentiation by using protein transduction domain and its application
| Project/Area Number |
21791374
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Cerebral neurosurgery
|
|---|
| Research Institution | Yokohama City University |
|---|
Principal Investigator |
KUBO Atsuhiko 横浜市立大学, 医学研究科, 客員研究員 (80525030)
|
|---|
| Research Collaborator |
KANNO Hiroshi 横浜市立大学, 医学研究科, 客員准教授 (40244496)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 神経分化 / ペプチド |
|---|
| Research Abstract |
As central nervous system is not regenerated naturally, reproduce of the damaged brain/neuron is expected by transplant of neuronal stem cells. Topics clarified in this study are 1 ; neuronal differentiation potential of skin-derived precursor cells 2 ; control of an intra-cellular factor involved in neuronal differentiation by using peptide. We identified the skin-derived precursor cells had neuronal differentiation ability and the advantage that there was no necessary of gene manipulation for the cells from isolation to transplant procedure. I designed the peptide, there was little cytotoxicity, which introduced to control intracellular signaling enrolled of neuronal differentiation inducing factor. It was thought that the utilization of the skin-derive precursor cells were useful as exclusive law of the regenerative medicine at this time
|
