Spinal plasticity of new chronic cervical cord compression model in rat.

2010 Fiscal Year Final Research Report

• Project/Area Number: 21791388
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: University of Fukui
• Principal Investigator: KUBOTA Masahumi University of Fukui, 医学部附属病院, 理学療法士 (60422672)
• Project Period (FY): 2009 – 2010
• Keywords: 脊髄慢性圧迫 / 行動学的評価 / MR画像 / 前角細胞 / ラット

Research Abstract

In this study, we produced a new animal model of chronic cervical compression capable of reproducing the clinical course without laminectomy using rats. This model might reproduce characteristic features of clinical chronic cervical cord compression, including progressive motor and sensory disturbances after a latency and insidious neuronal loss; representing well the chronic compression of cervical spine cord in humans.

Research Products

• [Journal Article] Development of Chronic Cervical Cord Compression Model in Rat : Changes of the Neurological Behaviors, Radiological and Pathological Findings. (2011)
  • Author(s): Kubota M, Kobayashi S, Nonoyama T, Shimada S, Takeno K, Miyazaki T, Guerrero AR, Iwamoto H, Baba H.
  • Journal Title: J Neurotrauma. 28(3) Pages: 459-67
  • Peer Reviewed
• [Journal Article] ラット頚髄慢性圧迫モデルにおける最大トレッドミル速度を用いた客観的評価 (2010)
  • Author(s): 久保田雅史, 小林茂, 野々山忠芳, 竹野建一, 宮崎剛, 馬場久敏
  • Journal Title: 日本脊髄障害医学会誌 23(1) Pages: 51-52
• [Journal Article] ラット慢性頚椎脊柱管狭窄モデルにおける脊髄の変化:モデル作成一年後のMR像及び組織学的変化 (2009)
  • Author(s): 久保田雅史, 小林茂, 野々山忠芳, 竹野建一, 宮崎剛, 馬場久敏
  • Journal Title: 日本脊髄障害医学会誌 22(1) Pages: 138-139
• [Presentation] Changes of locomotor function and pathology after chronic compression of the cervical cord in rats. (2010)
  • Author(s): Kubota M, Kobayashi S, Matsuo H, Miyazaki T, Takeno K, Shimada S, Sasaki S, Baba H.
  • Organizer: 7th Combined meeting of the orthopaedic research societies
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-11-17
• [Presentation] ラット慢性頚髄圧迫モデルにおける病理学的変化 (2010)
  • Author(s): 久保田雅史, 小林茂, 松尾英明, 竹野建一, 宮崎剛, 馬場久敏
  • Organizer: 第45回日本脊髄障害医学会
  • Place of Presentation: 松本
  • Year and Date: 2010-10-22
• [Presentation] Production of Chronic Cervical Spinal Cord Compression Model in Rat.Changes of the Neurological Behaviors, Radiological And Pathological Features with Aging. (2010)
  • Author(s): Kubota M, Kobayashi S, Matsuo H, Miyazaki T, Takeno K, Shimada S, Sasaki S, Alexander G, Baba H.
  • Organizer: 56th Annual Meeting of the Orthopaedic Research Society(ORS)
  • Place of Presentation: New Orleans, Louisiana.
  • Year and Date: 2010-03-08
• [Presentation] ラット慢性頚椎脊柱管狭窄モデルにおけるトレッドミル最大歩行速度の検討 (2009)
  • Author(s): 久保田雅史, 小林茂, 佐々木伸一, 嶋田誠一郎, 松尾英明, 竹野建一, 宮崎剛, 馬場久敏
  • Organizer: 第44回日本脊髄障害医学会
  • Place of Presentation: 東京
  • Year and Date: 2009-11-12
• [Presentation] ラット頸髄慢性圧迫モデルの解析:行動学的評価, MR像, 病理学的検討 (2009)
  • Author(s): 久保田雅史, 小林茂, 佐々木伸一, 嶋田誠一郎, 松尾英明, 竹野建一, 宮崎剛, 岩本久雄, 馬場久敏
  • Organizer: 第24回日本整形学会基礎学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2009-11-06