2010 Fiscal Year Final Research Report
The function of glia limitans in spinal cord injury
| Project/Area Number |
21791398
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Okayama University |
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Principal Investigator |
YONEZAWA Tomoko Okayama University, 大学院・医歯薬学総合研究科, 助教 (30304299)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 脊椎脊髄病学 / 脊髄損傷 / アストログリア |
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| Research Abstract |
Astroglia form a glia limitans around the injured tissue after spinal cord injury. We used a mouse spinal cord injury model and found that the glia limitans was associated with the suppression of infiltration of inflammatory cells and the perivascular space provides a conduit for inflammatory cells to the expansion from the injury core. In addition, we found that type IV collagen induced expression of thrombospondin-1 in astrocytes. Our results suggest that glia limitans play an important role in the repair process following injured central nervous tissue.
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