2010 Fiscal Year Final Research Report
The antitumor effect of histone deacetylase inhibitor against multidrug-resistant Ewing' s sarcoma cells
| Project/Area Number |
21791409
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Kitasato University |
|---|
Principal Investigator |
OKADA Takamitsu Kitasato University, 医学部, 講師 (70525550)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | 多剤耐性因子 / ピストン脱アセチル化酵素阻害剤 / オートファジー / ユーイング肉腫 / アポトーシス抵抗性 |
|---|
| Research Abstract |
We showed that histone deacetylase inhibitor SAHA induced apoptosis against parental drug-sensitive Ewing's sarcoma cells, however induced autophagic cell death against multidrug-resistant cells which was resistant to the apoptosic signals. Furthermore, we showed that SARA exhibited the antitumor effect against the animal model of multidrug-resistant Ewing's sarcoma.
|
