2011 Fiscal Year Final Research Report
Expression and functional analysis of CD44 and ADAM17in bone and soft tissue tumors
| Project/Area Number |
21791413
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 癌 / シグナル伝達 / 遺伝子 / 蛋白質 |
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| Research Abstract |
Many types of epithelial cancer are known to show their invasive motility and metastatic potential through a process called Epithelial-Mesenchymal Transition(EMT), in which cancer cells lose their epithelial morphology and acquire mesenchymal characteristics. We analyzed the clinical samples to elucidate expression and functions of CD44and TNFαconverting enzyme(TACE/ADAM17), key molecules in EMT, in primary malignant bone and soft tissue tumors which originally arise in the mesenchymal tissue.
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