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2010 Fiscal Year Final Research Report

Contributions of Cytogenetics and Molecular Genetics to the Diagnosis and Treatment of Malignant Soft Tissue Tumors

Research Project

  • PDF
Project/Area Number 21791424
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionFukuoka University

Principal Investigator

NISHIO Jun  Fukuoka University, 医学部, 助教 (90360304)

Project Period (FY) 2009 – 2010
Keywords軟部腫瘍 / 悪性線維性組織球腫 / 脂肪肉腫 / 色素性絨毛結節性滑膜炎 / 細胞株
Research Abstract

We established a new permanent human malignant fibrous histiocytoma cell line. Molecular cytogenetic analyses revealed a homozygous deletion of p16 and a high-level amplification of 9q31-34 in this cell line. CSFJ rearrangement was identified in about 60% of pigmented villonodular synovitis/giant cell tumor of tendon sheath cases. Also, the presence of CSFIR amplification was not identified in any cases examined. High-level amplification of 12q13-15 was found in well-differentiated liposarcomas and dedifferentiated liposarcomas but not in benign adipocytic tumors.

  • Research Products

    (15 results)

All 2011 2010 2009 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (7 results)

  • [Journal Article] Contributions of cytogenetics and molecular cytogenetics to the diagnosis of adipocytic tumors.2011

    • Author(s)
      Nishio J.
    • Journal Title

      J Biomed Hiotechnol 2011

      Pages: 524067

    • Peer Reviewed
  • [Journal Article] A novel t(4 ; 22)(q31 ; q12) produces an EWSR1-SMARCA5 fusion in extraskeletal Ewing sarcoma/primitive neuroectodermal tumor.2011

    • Author(s)
      Sumegi J, Nishio J, Nelson M, Frayer RW, Perry D, Bridge JA.
    • Journal Title

      Mod Pathol 24(3)

      Pages: 333-342

    • Peer Reviewed
  • [Journal Article] Establishment of a new human pleomorphic malignant fibrous histiocytoma cell line, FU-MFH-2 : molecular cytogenetic characterization by multicolor fluorescence in situ hybridization and comparative genomic hybridization.2010

    • Author(s)
      Nishio J, Iwasaki H, Nabeshima K, Ishiguro M, Isayama T, Naito M.
    • Journal Title

      J Exp Clin Cancer Res 29

      Pages: 153

    • Peer Reviewed
  • [Journal Article] Non-traumatic myositis ossificans mimicking a malignant neoplasm in an 83-year-old woman : a case report.2010

    • Author(s)
      Nishio J, Nabeshima K, Iwasaki H, Naito M.
    • Journal Title

      J Med Case Reports 4

      Pages: 270

    • Peer Reviewed
  • [Journal Article] Serum CA 125 expression as a tumor marker for diagnosis and monitoring the clinical course of epithelioid sarcoma.2010

    • Author(s)
      Hoshino M, Kawashima H, Ogose A, Kudo N, Ariizumi T, Hotta T, Umezu H, Hatano H, Morita T, Nishio J, Iwasaki H, Endo N.
    • Journal Title

      J Cancer Res Clin Oncol 136(3)

      Pages: 457-464

    • Peer Reviewed
  • [Journal Article] Aberrations of 6q13 mapped to the COL12A1 locus in chondromyxoid fibroma.2009

    • Author(s)
      Yasuda T, Nishio J, Sumegi J, Kapels KM, Althof PA, Sawyer JR, Reith JD, Bridge JA.
    • Journal Title

      Mod Pathol 22(11)

      Pages: 1499-1506

    • Peer Reviewed
  • [Journal Article] Pathology of soft-tissue tumors : daily diagnosis, molecular cytogenetics and experimental approach.2009

    • Author(s)
      Iwasaki H, Nabeshima K, Nishio J, Jimi S, Aoki M, Koga K, Hamasaki M, Hayashi H, Mogi A.
    • Journal Title

      Pathol Int 59(8)

      Pages: 501-521

    • Peer Reviewed
  • [Journal Article] Elastofibroma dorsi : diagnostic and therapeutic algorithm.

    • Author(s)
      Nishio J, Isayama T, Iwasaki H, Naito M.
    • Journal Title

      J Shoulder Elbow Surg in press.

    • Peer Reviewed
  • [Presentation] Establishment of a new human pleomorphic malignant fibrous histiocytoma cell line, FU-MFH-2 : molecular cycogenetic characterization by multicolor fluorescence in situ hybridization and comparative genomic hybridization.2010

    • Author(s)
      Nishio J, Iwasaki H, Nabeshima K, Ishiguro M, Isayama T, Naito M.
    • Organizer
      The Combined Conference of 16th Triennial Congress of Asia Pacific Orthopaedic Association and 59th Annual Meeting of Taiwan Orthopaedic Association
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2010-11-06
  • [Presentation] 分子機構に基づく色素性絨毛結節性滑膜炎/腱鞘巨細胞腫の診断と治療戦略2010

    • Author(s)
      西尾淳、内藤正俊、Julia Bridge
    • Organizer
      第43回日本整形外科学会骨・軟部腫瘍学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-16
  • [Presentation] 骨髄由来間葉系幹細胞の肉腫発生における関与について2010

    • Author(s)
      自見至郎、鍋島一樹、青木光希子、濱崎慎、西尾淳、岩崎宏
    • Organizer
      第43回日本整形外科学会骨・軟部腫瘍学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-15
  • [Presentation] 悪性末梢神経鞘腫瘍(MPNST)におけるPDG-FR-βの発現とimatinib mesylate(Gleevec)による治療の可能性について2010

    • Author(s)
      大石純、青木光希子、岩崎宏、鍋島一樹、古賀佳織、西尾淳、生越章、竹内保、箱崎道之
    • Organizer
      第43回日本整形外科学会骨・軟部腫瘍学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-15
  • [Presentation] 足関節に発生した粘液型脂肪肉腫の治療経験2010

    • Author(s)
      西尾淳、諫山照刀、吉村一朗、大慈弥裕之、岩崎宏、内藤正俊
    • Organizer
      第119回西日本・災害外科学会
    • Place of Presentation
      福岡
    • Year and Date
      2010-06-06
  • [Presentation] 軟骨粘液線維腫の染色体異常とFISH法を川いた分子細胞遺伝学的検討2009

    • Author(s)
      安田剛敏、西尾淳、金森昌彦、堀岳史、鈴木賀代、木村友厚、Juha Bridge
    • Organizer
      第42回日本整形外科学会骨・軟部腫瘍学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2009-07-17
  • [Presentation] 軟部腫瘍におけるテロメラーゼによらないテロメア安定機構2009

    • Author(s)
      石黒昌子、岩崎宏、西尾淳、濱田義浩、濱崎慎、青木光希子、鍋島一樹、平野公一、川本研一郎、原田泰志、池田丈明、茂木愛、松島悠、林博之、三宅徹
    • Organizer
      第42回日本整形外科学会骨・軟部腫瘍学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2009-07-17

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Published: 2012-02-13   Modified: 2016-04-21  

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