establish method of measurement for plasma cncentration of dexmedetomidine

2010 Fiscal Year Final Research Report

• Project/Area Number: 21791428
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Asahikawa Medical College
• Principal Investigator: KUROSAWA Atsushi Asahikawa Medical College, 医学部, 助教 (30463756)
• Project Period (FY): 2009 – 2010
• Keywords: 麻酔学

Research Abstract

We established the method for measurement of plasma concentration of dexmedetomidine, a sedative medication widely used by intensive care units in Japan. We extracted dexmedetomidine with gas chromatography-negative ion chemical ionization mass spectrometry. The quantification of dexmedetomidine became possible by this method with diazepam as internal standard substance.

Research Products

• [Journal Article] Importance of model fitting when a non-commercial TCI system was used : taking Kataria's parameter as an example. (2011)
  • Author(s): Kunisawa T, Kurosawa A, Hayashi D, Suzuki A, Takahata O, Iwasaki H.
  • Journal Title: J Anesth. 25(2) Pages: 314-315
• [Journal Article] Dexmedetomidine was safely used for sedation during spinal anesthesia in a very elderly patient. (2010)
  • Author(s): Kunisawa T, Hanada S, Kurosawa A, Suzuki A, Takahata O, Iwasaki H.
  • Journal Title: J Anesth. 24(6) Pages: 938-941
• [Journal Article] Effect of the initial loading dose of dexmedetomidine on hemodynamics in pediatric patients undergoing cardiac surgery (2010)
  • Author(s): Hayashi D, Kunisawa T, Kurosawa A, Nagashima M, Takahata O, Hiroshi I.
  • Journal Title: Masui. 59(3) Pages: 362-365