2010 Fiscal Year Final Research Report

The neuroprotective effects of a combination of post-ischemic dexmedetomidine and hypothermia after transient forebrain ischemia in rats

Research Project

Project/Area Number	21791430
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Anesthesiology/Resuscitation studies
Research Institution	Akita University
Principal Investigator	SATO Koji Akita University, 医学部, 助教 (80333938)
Project Period (FY)	2009 – 2010
Keywords	一過性前脳虚血 / デクスメデトミジン / 虚血後投与 / 低体温 / 短期予後 / 長期予後
Research Abstract	The combination of post-ischemic dexmedetomidine and hypothermia provided comparable short-term neuroprotection with either of the two therapies alone after transient forebrain ischemia in rats. The combination of pre-ischemic dexmedetomidine and hypothermia improved long-term histological outcome of hippocampal CA1 neurons compared with either of two therapies alone.

(4 results)