2011 Fiscal Year Final Research Report

The role of spinal microglial activation on postoperative pain-comparison with neuropathic pain-

Research Project

Project/Area Number	21791431
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Anesthesiology/Resuscitation studies
Research Institution	Gunma University
Principal Investigator	MIEDA Rie 群馬大学, 医学部, 医員 (10400772)
Project Period (FY)	2009 – 2011
Keywords	脊髄グリア細胞 / 術後痛 / 神経障害性疼痛
Research Abstract	The purpose of this study was to evaluate role of spinal microglia for hypersensitivity in postoperative pain and neuropathic pain. For postoperative pain, using rat model of postoperative pain, microglial inhibitors were injected into rats with paw incision to examine the role of spinal microglia in postoperative hypersensitivity In neuropathic pain model, rats were received microglial inhibitors immediately, 2 weeks and 2 months after L5 spinal nerve transection to determine when microglia have a most important role in the development and maintenance of neuropathic pain. I finished 70% of this study right now. Therefore, I will do my best to continue and complete this study.