2011 Fiscal Year Final Research Report
The analgesic effects of neurosteroids at the level of spinal cord
| Project/Area Number |
21791439
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Niigata University |
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Principal Investigator |
IKOMA Miho 新潟大学, 医歯学総合病院, 講師 (30432082)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 疼痛管理学 / 脊髄 |
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| Research Abstract |
We investigated the effects of neurosteroids, DHEA and DHEAS on excitatory synaptic transmission in the dorsal horn neurons of the adult rat spinal cord using electrophysiological technique. We found that neurosteroids, DHEA and DHEAS also increased the release of the excitatory transmitter. These data indicate that DHEA and DHEAS modulate the excitability of dorsal horn neurons.
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