2011 Fiscal Year Final Research Report
Analgesic effects ofα2-adrenoceptor agonist in morphine-tolerant rats.
| Project/Area Number |
21791441
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Niigata University |
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Principal Investigator |
ISHII Hideaki 新潟大学, 医歯学総合病院, 助教 (60529775)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 疼痛管理学 / オピオイド / モルヒネ / 耐性 / α2受容体作動薬 |
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| Research Abstract |
It was revealed using whole-cell patch-clamp technique that a selectiveα2-adrenoceptor agonist contributed to its antinociceptive action throughα2A-andα2C-adrenoceptors in the spinal cord. In behavioral experiments, fentanyl was injected 4 times at 15-min intervals. Subsequently, morphine was injected at the end of the fentanyl effects. Withdrawal latencies did not decrease below baseline values in the hot plate test. Withdrawal latencies also remained steadily elevated during continuous high-dose remifentanil administration. These findings suggest that acute high-dose opioid treatment might prevent the development of opioid tolerance.
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