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2010 Fiscal Year Final Research Report

Identification of intracellular factors involved in the prevention of arrhythmias induced by volatile anesthetics.

Research Project

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Project/Area Number 21791447
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Anesthesiology/Resuscitation studies
Research InstitutionOsaka University

Principal Investigator

IWASAKI Mitsuo  Osaka University, 医学部附属病院, 医員 (80528365)

Co-Investigator(Renkei-kenkyūsha) HAYASHI Yukio  大阪大学, 医学系研究科, 准教授 (60294063)
Project Period (FY) 2009 – 2010
Keywords不整脈 / 揮発性麻酔薬 / タンパク質 / リン酸化
Research Abstract

Activation of pertussis toxin-sensitive G protein, phosphatidylinositol 3-kinase-Akt-GSK3・signaling pathway and endogenous nitric oxide may be involved in prevention of adrenaline-induced arrhythmias during halothane anesthesia.

  • Research Products

    (4 results)

All 2010 2009 2008

All Journal Article (3 results) Presentation (1 results)

  • [Journal Article] Activation of phosphatidylinositol 3-kinase/Akt signaling pathway and endogenous nitric oxide are needed for the antiarrhythmic effect of centrally administered rilmenidine.2010

    • Author(s)
      Yamanaka H, Hayashi Y, Iwasaki M, Kamibayashi T, Yamatodani A, Mashimo T.
    • Journal Title

      Eur J Pharmacol 647

      Pages: 155-160

  • [Journal Article] プレコンディショニングと麻酔への臨床応用2009

    • Author(s)
      山中寛男、林行雄
    • Journal Title

      麻酔 58

      Pages: 279-87

  • [Journal Article] The antiarrhythmic effect of centrally admoinistered rilmenidine involves muscarinic receptors, protein kinase C, and mitochontrial signalling pathways.2008

    • Author(s)
      Iwasaki M, Hayashi Y, Kamibayashi T, Ymatodani A, Mashimo T.
    • Journal Title

      Br J Pharmacol 153

      Pages: 1623-30

  • [Presentation] 迷走神経を介したリルメニジンの抗不整脈作用におけるPTX感受性G蛋白およびPI3K/Aktシグナル伝達の働き2010

    • Author(s)
      山中寛男、林行雄、岩崎光生、上林卓彦、真下節
    • Organizer
      第31回日本循環制御医学会
    • Place of Presentation
      大阪
    • Year and Date
      20100500

URL: 

Published: 2012-02-13   Modified: 2016-04-21  

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