2010 Fiscal Year Final Research Report
The mechanisms of cytokine-induced encephalopathy and influence on anesthesia
| Project/Area Number |
21791461
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
HAYASHI Shiho Fukushima Medical University, 医学部, 博士研究員 (60443868)
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| Co-Investigator(Renkei-kenkyūsha) |
MURAKAWA Masahiro 福島県立医科大学, 医学部, 病院長 (90182112)
TAKAHASHI Shinichiro 福島県立医科大学, 医学部, 助教 (50457769)
HAKOZAKI Takahiro 福島県立医科大学, 医学部, 病院助手 (60595429)
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| Project Period (FY) |
2009 – 2010
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| Keywords | サイトカイン / アセチルコリン / 催眠作用 |
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| Research Abstract |
I conducted research to confirm if cytokine levels affect acetylcholine neuron. Lipopolysaccharide was injected to rats intraperitoneally. Microdialysis probe was inserted into brain and samples were obtained. The acetylcholine levels were measured using HPLC system. Our results showed that the extracellular acetylcholine levels of rat brain after LPS injection were not significantly different from control levels.
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