2010 Fiscal Year Final Research Report
Effects of vecuronium bromide on central respiratory control and its passage through blood brain barrier in the in vivo rabbits
| Project/Area Number |
21791479
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Kanagawa Dental College |
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Principal Investigator |
SAKURABA Shigeki Kanagawa Dental College, 歯学部, 非常勤講師 (00383729)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 筋弛緩薬 / 呼吸中枢 / 呼吸抑制 |
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| Research Abstract |
Muscle relaxants used during operation are thought to cause postoperative respiratory depression due to their effects on respiratory muscles. However, in the animal experiment using newborn rats isolated-medulla, muscle relaxants also suppress central respiratory control. Therefore, in this experiment, effects of muscle relaxants injected peripheral vein on central respiratory control were analysed using the in vivo rabbits. Finally, it was found that high dose muscle relaxants suppressed respiratory control also in the in vivo rabbits
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