2011 Fiscal Year Final Research Report
Analysis of the action mechanisms of volatile anesthetics and analgesics aimed at development of selective sodium channel blocker
| Project/Area Number |
21791480
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OOKURA Dan 産業医科大学, 医学部, 研究員 (00596710)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 疼痛管理学 |
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| Research Abstract |
We investigated the effects of analgesics on voltage-gated sodium channels electrophysiologically using Xenopus oocyte expression system to contribute the development of new analgesics for intractable pain. We demonstrated that some neurosteroids and endocannabinoid having analgesic action inhibited some Navα subunits functions, suggesting that this effect is one of the action mechanisms of these analgesics.
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Research Products
(2 results)
