2011 Fiscal Year Final Research Report
The effect of subthalamic nucleus deep brain stimulation (STN-DBS) on the neuronal activity and the neurotransmitter in higher micturition centre
| Project/Area Number |
21791489
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Chiba University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 泌尿器科学 |
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| Research Abstract |
We initially investigated the effect of subthalamic nucleus deep brain stimulation (STN-DBS) on the micturition reflex, local field potential in the STN, and the levels of catecholamine in the striatum, respectively. STN-DBS significantly inhibit the micturition reflex and increase the power in the . frequency (around 20Hz) in STN. Dopamine metabolites (DOPAC and HVA) in the striatum were slightly increased by STN-DBS without statistically significance. In the next, we generated Parkinson's disease model rat (PD rat) by stereotaxically injecting 6-OHDA into the medial forebrain bundle in normal rat. STN-DBS significantly inhibited micturiton reflex in some PD rats and the power in the . frequency in STN. Striatal DOPAC was significantly decreased by STN-DBS.
This study showed that the effect of STN-DBS was different between normal and PD model rat, which might be important in examining the physiological mechanisms of STN-DBS.
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