2011 Fiscal Year Final Research Report
The association of intracellular localization and expression of ATBF1 with the malignant potential of prostate cancer
| Project/Area Number |
21791493
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Niigata University |
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Principal Investigator |
HARA Noboru 新潟大学, 医歯学総合病院, 助教 (50397113)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 前立腺癌 / ATBF1 / 予後診断 / 内分泌療法 / 分子機構 |
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| Research Abstract |
Loss of ATBF1 was associated with the high malignant potential in prostate cancer. Processing of ATBF1 may be involved in the alteration of cell cycle markers, which are indices for susceptibility to androgen deprivation. In androgen receptor-active prostate cancer cells, transcription levels of androgen-responsive KLKs were upregulated by adrenal androgens in a concentration-dependent manner. The present study verified that androgen synthesis mediated by the pituitary-adrenal axis is a potential target for advanced ADT.
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[Journal Article] External validation of the UCSF-CAPRA(University of California, San Francisco, Cancer of the Prostate Risk Assessment) in Japanese patients receiving radical prostatectomy2011
Author(s)
Ishizaki F, Hoque MA, Nishiyama T, Kawasaki T, Kasahara T, Hara N, Takizawa I, Saito T, Kitamura Y, Akazawa K, Takahashi K
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Journal Title
Japanese Journal of Clinical Oncology
Volume: 41(11)
Pages: 1259-64
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