2010 Fiscal Year Final Research Report
Research of the mechanisms of taxan drug resistance in prostate cancer
| Project/Area Number |
21791495
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Urology
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
MIWA Sotaro Kanazawa University, 附属病院, 助教 (80507070)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | 腫瘍学 |
|---|
| Research Abstract |
To determine the mechanisms of paclitaxel resistance in PC-3-TxR cells, we compared the gene expression profiles between PC-3 and PC-3-TxR cells. Our results indicated that expression of the C-terminal tensin like protein (CTEN, tensin 4) gene was down-regulated by 10-fold in PC-3-TxR cells. CTEN expression was inversely correlated with F-actin and EGFR expression. Then knockdown of actin and EGFR in PC-3-TxR cells recovered paclitaxel sensitivity, indicating that CTEN down-regulation mediates paclitaxel resistance through elevation of EGFR and actin expression.
|
