2010 Fiscal Year Final Research Report

Reseaarch on the function and development of new therapy for Ion channels in the lower urinary tract

Research Project

Project/Area Number	21791497
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Urology
Research Institution	University of Yamanashi
Principal Investigator	KUDOU Shouji University of Yamanashi, 医学部附属病院, 助教 (10313800)
Project Period (FY)	2009 – 2010
Keywords	排尿学
Research Abstract	Boturinum toxin (Botox) has been widely used for refractory overactive bladder(OAB), and its mechanism of action in OAB has been examined. In this study, we have been trying to explore the novel, afferent inhibiton of Botox. In the urine storage phase, mechanical stretch stimulates bladder afferents. These urinary bladder afferent sensory nerves consist of small diameter Aδ-and C-fibers running in the hypogastic and pelvic nerves. Neuroanatomical studies have revealed a complex neuronal network within the bladder wall. The exact mechanisms that underline mechano-sensory transduction in bladder afferent terminals remain ambiguous.