2010 Fiscal Year Final Research Report
The effect of RAS inhibitor on remnant kidney function and long-term allograft survival in living-donor kidney transplantation
| Project/Area Number |
21791507
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Kagawa University |
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Principal Investigator |
SOFUE Tadashi Kagawa University, 医学部附属病院, 病院助教 (80452671)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 生体腎移植 / マージナルドナー / 高血圧 / 0時間腎生検 / 腎動脈硬化病変 / RAS阻害薬 / 腎内アンジオテンシンII / 正常高値アルブミン尿 |
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| Research Abstract |
Arteriosclerotic vasculopathy in the kidney on 0-hour biopsy sample is a risk factor for lower allograft function. Pre-treatment with ARB on hypertensive donor with microalbuminuria reduced microalbuminuria but could not induce remission of hypertensive nephrosclerosis in the pathological findings. In living-donor kidney transplantation, early intervention by ARBs from pre-operative period in living-donors who exhibit normal-high microalbuminuria is needed to prevent ischemic reperfusion damages.
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[Presentation] Early treatmentwith an angiotensin receptor blockerprevents the onset of podocyte injuryand microalbuminuria in type 2diabetic rats.2010
Author(s)
Tadashi Sofue, Hideyasu Kiyomoto,Satoshi Nishioka, Yoko Nishijima,Kumiko Kaifu, Taiga Hara, DaisukeNakano, Hirofumi Hitomi, HiroshiKawachi, Hiroyuki Kobori, MasakazuKohno Akira Nishiyama
Organizer
ISN-NEXUS 2010 KYOTO.
Place of Presentation
京都市
Year and Date
2010-04-18
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