2011 Fiscal Year Final Research Report
Analysis ofβ2-microglobulin mediated signaling in renal cell carcinoma growth and its bone metastasis
Project/Area Number |
21791512
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Urology
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Research Institution | Oita University |
Principal Investigator |
NOMURA Takeo 大分大学, 医学部, 講師 (40347034)
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Project Period (FY) |
2009 – 2011
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Keywords | 腫瘍学 |
Research Abstract |
This study demonstrates for the first time howβ2-microglobulin(β2-M) supports lethal metastasis in vivo in human renal cancer cells(SN12C).β2-M mediates this process by activating epithelial to mesenchymal transition(EMT) to promote lethal bone and soft tissue metastases in host mice. These results demonstrate the role ofβ2-M in renal cancer metastasis and lethality. Thus,β2-M and its downstream signaling pathways are promising prognostic markers of renal cancer metastases and novel therapeutic targets for cancer therapy using anti-β2-M antibody.
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Research Products
(4 results)