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2010 Fiscal Year Final Research Report

Effect of androgen receptor on apoptosis induction in androgen- independent prostate cancer cells

Research Project

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Project/Area Number 21791514
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionGifu Pharmaceutical University

Principal Investigator

IGUCHI Kazuhiro  Gifu Pharmaceutical University, 薬学部, 助教 (10295545)

Project Period (FY) 2009 – 2010
KeywordsLNCaP細胞 / LNCaP-E9細胞 / AIDL細胞 / アンドロゲン受容体 / アポトーシス
Research Abstract

Low-androgen-sensitive LNCaP-E9 cells and androgen-independent AIDL cells were established from androgen receptor-positive prostate cancer LNCaP cells. Androgen receptor was expressed in LNCaP-E9 and AIDL cells. Low androgen sensitivity in LNCaP-E9 cells was associated with reduced Akt phosphorylation. W741C and T877A mutations were found in AIDL cells and the mutations may explain the androgen resistance of AIDL cells.

  • Research Products

    (6 results)

All 2011 2010 2009

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (1 results)

  • [Journal Article] Castration-and aging-induced changes in the expression of zinc transporter and metallothionein in rat prostate.2011

    • Author(s)
      Iguchi, K., Morihara, N., Usui, S., Hayama, M., Sugimura, Y., Hirano, K.
    • Journal Title

      J.Androl. 32

      Pages: 144-150

    • Peer Reviewed
  • [Journal Article] Pamidronate inhibits anti-apoptotic bcl-2 expression through inhibition of the mevalonate pathway in prostate cancer PC-3 cells.2010

    • Author(s)
      Iguchi, K., Tatsuda, Y., Usui, S., Hirano, K.
    • Journal Title

      Eur.J.Pharmacol. 641

      Pages: 35-40

    • Peer Reviewed
  • [Journal Article] Protein kinase C is inhibited by bisphosphonates in prostate cancer PC-3 cells.2010

    • Author(s)
      Tatsuda, Y., Iguchi, K., Usui, S., Suzui, M., Hirano, K.
    • Journal Title

      Eur.J.Pharmacol. 627

      Pages: 348-353

    • Peer Reviewed
  • [Journal Article] Evidence that androgen-independent stromal growth factor signals promote androgen -insensitive prostate cancer cell growth in vivo.2009

    • Author(s)
      Ishii, K., Imamura, T., Iguchi, K., Arase, S., Yoshio, Y., Arima, K., Hirano, K., Sugimura, Y.
    • Journal Title

      Endocr.Relat.Cancer 16

      Pages: 415-428

    • Peer Reviewed
  • [Journal Article] Overexpression of thymosin beta4 increases pseudopodia formation in LNCaP prostate cancer cells.2009

    • Author(s)
      Ito, M., Iguchi, K., Usui, S., Hirano, K.
    • Journal Title

      Biol.Pharm.Bull. 32

      Pages: 1101-1104

    • Peer Reviewed
  • [Presentation] Characterization of androgen-low sensitive LNCaP subline, LNCaP-E9 cells2010

    • Author(s)
      Kazuhiro Iguchi, Kazuhiro Fukami, Kenichiro Ishii, Shigeyuki Usui, Yoshiki Sugimura, Kazuyuki Hirano
    • Organizer
      International Society for Onco- developmental Biology and Medicine (ISOBM)
    • Place of Presentation
      Munich, Germany.
    • Year and Date
      20100904-20100908

URL: 

Published: 2012-02-13   Modified: 2016-04-21  

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